预后因素和竞争性风险分析在早期的卵泡性甲状腺癌:一个基于人口的研究
Isa Karaca1, Ahmet Necati Sanli2, Bilal Turan1
1Department of General Surgery, Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey.
The American surgeon
|January 22, 2026
概括
早期卵泡性甲状腺癌 (FTC) 的癌症特异性死亡率较低. 然而,AJCCII期FTC患者面临的风险高于I期,这表明在早期阶段存在显著的异质性.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 毛囊性甲状腺癌 (FTC) 与乳头性甲状腺癌相比表现出不同的行为.
- 虽然早期的FTC通常具有有利的结果,但由于有限的具体证据,AJCC I-II阶段的风险分层需要进一步调查.
研究的目的:
- 分析患有AJCCI-II期卵泡性甲状腺癌的患者的疾病特异性生存率 (DSS) 和死亡原因.
- 用竞争风险方法确定早期FTC死亡率的预后因素.
主要方法:
- 利用SEER数据库识别了在2010年至2022年期间被诊断患有AJCCI-II期FTC的4220名患者.
- 使用累积发病率函数 (CIF) 来估计甲状腺癌特异性和其他原因死亡率.
- 应用细灰竞争风险回归来评估预后因素.
主要成果:
- 在随访期间,其他原因的死亡率超过了甲状腺癌特定的死亡率.
- 大约10年后,其他原因的死亡率约为6%,而甲状腺癌的特定死亡率仍低于1.5%.
- 与I期相比,AJCCII期被确定为甲状腺癌特异性死亡率的唯一显著预测因素 (SHR7.76;P=0.002).
结论:
- 早期的FTC表明癌症特异性死亡率总体较低,但在II阶段存在集中风险.
- 这突显了"早期阶段"分类中的临床显著异质性.
- 结果支持量身定制的患者咨询和后续策略,强调FTC结果评估中竞争风险方法的实用性.
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