接受激素治疗的乳腺癌患者的功能性失联
Julie Petersen1,2, Sonya V Gupta3, Alexandra C Apple4
1Division of Clinical Psychology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Journal of clinical and experimental neuropsychology
|January 22, 2026
概括
接受激素治疗的乳腺癌患者表现出显著的大脑网络变化,特别是头顶尾区域的连接性降低. 这些神经变化与认知功能相关,影响生活质量.
科学领域:
- 神经成像是一种神经成像.
- 在瘤学瘤学.
- 神经科学是一个神经科学.
背景情况:
- 乳腺癌的辅助激素治疗通常会导致不良反应,影响生活质量和治疗坚持.
- 激素治疗对大脑功能的具体影响,独立于其他治疗方法,研究不足.
- 雌激素在大脑中的广泛作用表明,激素治疗可能会导致扩散的神经效应.
研究的目的:
- 研究正在接受激素治疗的乳腺癌患者内在神经功能组织.
- 为了确定与这些神经变化相关的认知相关性.
- 为了区分激素治疗对大脑网络的影响.
主要方法:
- 休息状态功能磁共振成像 (rsFC) 用于评估大脑连接.
- 低频波动的分数振幅 (fALFF) 测量了区域大脑特性.
- 神经心理测试评估了认知功能,并与rsFC相关联.
主要成果:
- 与健康对照人群相比,乳腺癌患者表现出广泛的大脑失联.
- 主要观察到的低连接性主要发生在头顶-尾区域.
- 减少的rsFC与增加的fALFF有关,并且在患者中发现rsFC和视觉工作记忆之间存在温和的联系.
结论:
- 这是第一个分析激素治疗乳腺癌患者全脑rsFC的研究,揭示了强大的低连接性.
- 观察到的神经变化显示了与认知表现的适度关系.
- 了解这些激素治疗诱导的大脑网络变化可以为治疗策略提供信息,以改善癌症幸存者的生活质量.
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