在致命的马尔堡病毒和埃博拉病毒暴露后,在肝脏中肝细胞亡的机器学习支持量化
Yanling Liu1, Winston T Chu2, Syed Qasim Gilani2
1Integrated Data Sciences Section Research Technologies Branch, Division of Intramural Research, National Institutes of Allergy and Infectious Disease, Rockville, MD, USA.
The Journal of infectious diseases
|January 22, 2026
概括
深度学习模型量化了filovirus疾病中的肝损伤. 马尔堡病毒在 rhesus 子中比埃博拉病毒更严重地引起肝死.
科学领域:
- 病理学 病理学 病理学
- 病毒学 病毒学
- 人工智能的人工智能
背景情况:
- 肝脏是严重的filovirus感染的主要目标.
- 准确量化filovirus疾病肝脏病理目前是有限的.
研究的目的:
- 开发和验证深度学习模型,用于对马尔堡病毒 (MARV) 和埃博拉病毒 (EBOV) 感染的肝脏病理学的定量分析.
- 在非人类灵长类动物模型中比较MARV和EBOV之间的肝损伤模式.
主要方法:
- 深度学习模型被训练为像素级分段数字化肝病理幻灯片来自感染MARV,EBOV Makona或EBOV Kikwit的 rhesus子.
- 该模型量化了肝脏亡,动脉,静脉和胆管,对病理学家的变异性进行了性能评估.
- 肝酶 (AST,ALT,GGT,ALP) 被测量并与组织病理学发现相关联.
主要成果:
- 深度学习模型实现了与专家病理学家可比的亡细分.
- DL量化的肝脏亡与感染病毒有显著的相关性,MARV感染的子表现出最高的亡率 (11.0%).
- 氨酸氨基转移酶 (ALT) 水平与死严重程度相关,死局部在MARV (门道附近) 和EBOV (中央静脉附近) 感染之间有所不同.
结论:
- 深度学习提供了一种强大的方法,用于在菲洛病毒感染中对肝损伤的定量体病学分析.
- 在 rhesus 子中,MARV 感染会引起比 EBOV 感染更严重的肝硬化.
- 这种方法使得大规模的回顾性分析的filovirus诱导的肝脏病理学.
相关概念视频
Necrosis
6.4K
Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become...
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become...
6.4K
Lethal Alleles
17.7K
Agouti: A Lethal Allele
Lucien Cuénot discovered lethal alleles in 1905 while studying the inheritance of coat color in mice. The agouti gene is responsible for the color of the coat in mice. This gene codes for an agouti-signaling protein, which is responsible for melanin distribution in mammals. The wild-type allele gives rise to gray-brown coat color in mice, while the mutant allele gives rise to yellow coat color. In addition to coat color, the agouti gene is associated with the yellow...
Lucien Cuénot discovered lethal alleles in 1905 while studying the inheritance of coat color in mice. The agouti gene is responsible for the color of the coat in mice. This gene codes for an agouti-signaling protein, which is responsible for melanin distribution in mammals. The wild-type allele gives rise to gray-brown coat color in mice, while the mutant allele gives rise to yellow coat color. In addition to coat color, the agouti gene is associated with the yellow...
17.7K
Machines
559
Machines are complex structures consisting of movable, pin-connected multi-force members that work together to transmit forces. One example of a machine is the cutting plier, which is used to cut wires by applying forces to its handles. When equal and opposite forces are exerted on the handles of the cutting plier, they cause the cutting edges to come together and apply equal and opposite reaction forces on the wire, which are greater than the applied forces.
A free-body diagram of the...
A free-body diagram of the...
559
What are Viruses?
127.8K
Overview
127.8K
Machines: Problem Solving II
650
Machines are complex structures consisting of movable, pin-connected multi-force members that work together to transmit forces. Consider a lifting tong carrying a 100 kg load. It comprises movable sections DAF and CBG linked together with member AB.
650
Machines: Problem Solving I
697
A toggle clamp is a mechanical device commonly used for holding and clamping objects in various applications, such as woodworking, metalworking, and assembly operations. Consider a toggle clamp subjected to a force of 200 N at the handle. The vertical clamping force can be calculated, provided the dimensions of the toggle clamp are known.
The toggle clamp system is a machine structure consisting of movable, pin-connected multi-force members that form a stabilized system to transmit forces. The...
The toggle clamp system is a machine structure consisting of movable, pin-connected multi-force members that form a stabilized system to transmit forces. The...
697


