带血的基细胞激活测试可以预测牛奶过敏吗?
Dilara Fatma Kocacık Uygun1, Durmuş Burgucu2, Vedat Uygun3
1Pediatric Allergy-Immunology Department, Akdeniz University School of Medicine, Antalya, Turkey.
Clinical and experimental pediatrics
|January 22, 2026
概括
在带血中高素基激活测试 (BAT) 值可以预测婴儿食物过敏. 这一发现表明,素敏感性可能表明新生儿未来的过敏风险,需要进一步研究.
科学领域:
- 免疫学 免疫学 免疫学
- 儿科过敏 儿科过敏
背景情况:
- 食物过敏影响4-6%的儿童,通常在生命的头两年内发展.
- 婴儿过敏的预测标记物,如带血细胞和细胞因子正在接受研究.
- 早期免疫学标志物对食物过敏的准确预测价值仍然不清楚.
研究的目的:
- 调查带血的基基细胞激活测试 (BAT) 是否可以预测婴儿牛奶过敏.
- 评估用牛奶蛋白抗原 (牛奶和乳酪蛋白) 刺激基细胞对过敏预测的有用性.
主要方法:
- 从30对母亲和孩子的出生时收集了带血样本.
- 使用牛奶蛋白抗原 (牛奶和乳酪蛋白) 进行了基细胞激活测试 (BAT).
- 婴儿被监测了一年,以比较BAT结果与过敏的发展.
主要成果:
- 素-BAT值≥2.6的婴儿在第一年内发展食物过敏症状的可能性是33.2倍 (P=0.03).
- 牛奶特定的BAT值和牛奶敏感性之间没有发现显著的关联.
- 较高的素-BAT水平与食物过敏症状的出现有很强的相关性.
结论:
- 在带血中高素-BAT值可能作为预测标志物,预测生命的第一年食物过敏的发展.
- 用BAT表示的素敏感性可能是预测整体食物过敏风险的关键因素.
- 需要进一步的研究来验证素-BAT对婴儿食物过敏的预测能力.
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