破坏瘤的机械冲动 (TMI) 固体瘤的治疗. 第二部分:生物力学,计算模拟,技术发电机和应用器设计,以及生理效应
Axel Erich Theuer1, Nicolas Schierbaum2, Heike Niessner3
1Department of Dermatology, Venerology and Allergology, Charité University Hospital, Berlin, Germany.
概括
瘤破坏性机械冲动 (TMI) 为治疗固体瘤提供了一种新且有效的方法. 这项研究证明了TMI的存在.
科学领域:
- 生物物理学的生物物理.
- 生物机械工程 生物机械工程
- 在瘤学瘤学.
背景情况:
- 研究瘤破坏性机械冲动 (TMI) 作为一种新的癌症治疗方法.
- 区分TMI与现有疗法,如高强度聚焦超声波 (HIFU) 和瘤治疗场 (TTFs).
研究的目的:
- 评估TMI在固体瘤治疗中的可行性和有效性.
- 在细胞和组织中建立冲击波传播的计算模拟的生物力学先决条件.
主要方法:
- 使用原子力显微镜进行细胞力学分析.
- 执行用于冲击波传播的多参数计算模拟.
- 设计和评估TMI发电机和应用器.
- 进行光和电子显微镜,以评估治疗对瘤细胞和组织的影响.
主要成果:
- 通过基于细胞属性数据的模拟来确定最佳的TMI处理参数 (能量,流量密度,频率) 和应用器位置.
- 展示外体和内体TMI应用器的设计灵活性.
结论:
- 证实了TMI在固体瘤治疗中的基本可行性,有效性和可靠性.
- 为TMI治疗的临床转化建立理论基础.
相关概念视频
Design Example: Traverse Angle Computations
315
Traverse angle computations are a critical component of surveying, used to compute the internal angles within a closed traverse. A traverse consists of a series of connected lines forming a closed loop, often used for land boundary delineation or mapping. Calculating the internal angles ensures accuracy in the traverse geometry and is essential for checking survey data integrity.The process begins with known azimuths and bearings of the traverse sides. Internal angles at each vertex are...
315
Tumor Immunotherapy
1.8K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
1.8K
Tumor Progression
7.2K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
7.2K
The Tumor Microenvironment
7.6K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
7.6K
Design Example: Application of Archimedes' Principle
801
Archimedes' principle is fundamental in analyzing the buoyant force and stability of floating bodies. In this example, a wooden block with a rectangular section floats in seawater. Based on the block's dimensions, its specific gravity and the specific weight of seawater are used to find the volume of water displaced and the center of buoyancy.
The volume of seawater displaced by the block is determined by first calculating the block's weight. This is done by multiplying the...
The volume of seawater displaced by the block is determined by first calculating the block's weight. This is done by multiplying the...
801
Impulse
21.4K
According to Newton’s second law of motion, the rate of change of the momentum of an object is the net external force acting on it. The total change in momentum between two timepoints thus depends on both the external force acting on it and the time over which it acts. Describing this mathematically, the total change of an object’s motion is proportional to the force vector and the time over which it is applied. This product is called impulse.
Additionally, it can be shown that the...
Additionally, it can be shown that the...
21.4K


