在固体-油-水多层乳液中联合封装的黄素和富可桑丁的编程顺序释放行为和生物可用性
Luhui Wang1, Mingqing Wang1, Ling Lv2
1Shandong Peanut Research Institute Shandong Academy of Agricultural Sciences Qingdao China.
Food science & nutrition
|January 22, 2026
概括
这项研究开发了新型的多层乳液,用于同时输送黄素和富可桑丁,实现增强的生物利用性和在胃肠道 (GIT) 中的向释放. 该系统展示了编程的顺序释放,改善了营养物质的输送.
科学领域:
- 食品科学与技术 食品科学与技术
- 材料科学 材料科学 材料科学
- 生物技术是生物技术.
背景情况:
- 同时输送多种生物活性化合物对于提高生物可用性至关重要.
- 编程顺序释放系统可以针对胃肠道 (GIT) 中的特定部位.
- 食品级的输送系统对于安全有效的营养包装至关重要.
研究的目的:
- 为了构建食品级固体在油中-在水中的多层乳液 (S/O/W-E),用于联合交付.
- 为了在GIT中实现黄素 (Cur) 和黄素 (FUC) 的编程顺序释放.
- 评估S/O/W-E系统的体外和体内性能.
主要方法:
- 制造S/O/W-E使用碳甲基康雅克 (konjac glucomannan) 涂层的gliadin纳米颗粒,子油和碳甲基粉/乙烯基甘醇酸盐复合物.
- 在体外消化模型模拟胃,肠道和结肠环境.
- 在动物模型中进行体内生物可用性研究和光成像.
主要成果:
- 在模拟的胃液中,Cur和FUC的释放最小 (<16.5%).
- 在模拟的肠液中通过侵蚀释放的Cur (67.3%) 高.
- 在模拟的结肠液中显著释放FUC (60.3%),由β-mannanase和侵蚀介导.
- 在体内研究显示,Cur生物可用性增加了6.4倍,并向结肠提供了向的FUC.
结论:
- 开发的S/O/W-E系统有效地将Cur和FUC与编程顺序释放共同封装在一起.
- 该系统通过准小肠来增强Cur的生物可用性,并将FUC输送到结肠.
- 这项技术为扩大联合交付系统中多层乳液的应用提供了一个有前途的方法.
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