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Updated: Jan 23, 2026

Technique for Intranasal Administration of α-Synuclein Aggregates
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性结肠炎模型触发肠道α-Synuclein聚合在没有大脑参与或神经元损失的雌性大鼠

Ana María Espinosa-Oliva1,2, María Dolores Vázquez-Carretero3, Rocío Ruiz1,2

  • 1Instituto de Biomedicina de Sevilla, IBiS/Hospital Universitario Virgen del Rocío/CSIC/Universidad de Seville, Sevilla, Spain.

Frontiers in immunology
|January 22, 2026
PubMed
概括

性影响了帕金森病 (PD) 的进展. 虽然德克斯硫酸 (DSS) 诱导了两性肠道炎症和α-synuclein,但雌性大鼠没有发展出PD特征的脑病理.

关键词:
帕金森病是帕金森病的一种疾病.肠-大脑轴 肠-大脑轴这是一种炎症炎症炎症炎症.神经退行症的神经退行症性别差异的性别差异.性结肠炎是一种α-Synuclein 是一种蛋白质.

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