基底质介导复杂的工具使用技能的半球间转移
Sayori Takeda1, Kouji Takano1, Kimihiro Nakamura1
1Section of Systems Neuroscience, National Rehabilitation Center for Persons with Disabilities, Tokorozawa 359-8555, Japan.
iScience
|January 22, 2026
概括
学习用一只手使用复杂的工具可以通过大脑的可塑性来提高另一只手的性能. 这种手间转移涉及大脑连接的变化,特别是在背部前运动皮质和基底腺节.
科学领域:
- 神经科学是一个神经科学.
- 发动机控制器的控制器
- 认知科学 认知科学
背景情况:
- 一只手获得的运动技能可以转移到另一只手,这种现象被称为手间转移.
- 在复杂的工具使用学习过程中,基础上的神经机制还不太清楚.
研究的目的:
- 为了研究学习使用一种新的复杂工具与右手个体的非主导左手的神经行为效应.
- 识别在工具使用学习期间与人工间转移相关的大脑区域和功能连接变化.
主要方法:
- 使用了休息状态功能磁共振成像 (fMRI).
- 参与者是右撇子,他们被训练用左手使用一种新的复杂工具.
- 在训练前和训练后,对两只手的工具使用行为表现进行了评估.
- 分析了特定大脑区域之间的功能连接,包括背部前运动皮质 (PMd) 和腹内 (IPS),以及基底 (BG).
主要成果:
- 用左手进行工具使用训练导致左手和未经训练的右手的性能显著提高,证实了强大的手间传输.
- 两只手的行为改善与右背前运动皮质 (PMd) 和腹内 (IPS) 之间的功能连接的变化相关.
- 对于未经训练的右手,在右基底 (BG) 与双边PMd中观察到性能和连接性之间的相关性增加.
结论:
- 通过左手训练获得的复杂的工具使用技能,在右手PMd-IPS网络中表示.
- 这种学到的技能被转移到左手PMd上,该PMd负责右手的表现,突出了基底质在将复杂的运动技能泛化到手上的关键作用.
相关概念视频
Cerebral Hemispheres
2.2K
The human brain, a complex organ, is functionally divided into two cerebral hemispheres—left and right. These hemispheres are interconnected by a structure of paramount importance, the corpus callosum. This substantial bundle of neural fibers is not just a bridge between the hemispheres but a crucial element for the brain's comprehensive functioning. It enables efficient communication between the two hemispheres, allowing each side of the brain to control and receive sensory and motor...
2.2K
Laminins are the Adhesive Proteins of Basal Lamina
3.1K
Laminins are heterotrimeric proteins with high molecular mass found in the extracellular matrix. Each laminin molecule is composed of three chains, viz. alpha, beta, and gamma, coded by five, four, and three paralogous genes, respectively. Laminins are categories based on the compositions of the three chains.
In humans, the five forms of alpha chains are LAMA 1, LAMA 2, LAMA 3, LAMA 4, and LAMA 5. The four forms of beta chains are LAMB 1, LAMB 2, LAMB 3, and LAMB 4. The three forms of gamma...
In humans, the five forms of alpha chains are LAMA 1, LAMA 2, LAMA 3, LAMA 4, and LAMA 5. The four forms of beta chains are LAMB 1, LAMB 2, LAMB 3, and LAMB 4. The three forms of gamma...
3.1K
Basal Lamina are the Specialized Form of ECM
3.7K
The basal lamina is a thin extracellular layer that lies underneath the cells and separates them from other tissues. The three layers of the basal lamina are lamina lucida, lamina densa and lamina reticularis. The basal lamina, a mixture of glycoproteins and collagen, provides an attachment site for the epithelium, separating it from underlying connective tissue. The framework of basal lamina has other essential proteins such as laminins mesh, perlecan, entactin, and type IV collagen.
Proteins...
Proteins...
3.7K
Type IV Collagen of Basal Lamina
3.0K
Type IV collagen is a 400 nm long, network-forming collagen that acts as a barrier between the epithelial and endothelial cells. Type IV collagen forms the backbone of the basement membrane by scaffolding with laminin, entactin, proteoglycans, and fibronectin. Apart from rendering structural support to the basement membrane, it also helps entail signaling potentials necessary for both pathological and physiological functions.
A type IV collagen molecule has six alpha chains which can...
A type IV collagen molecule has six alpha chains which can...
3.0K
Types of Genetic Transfer Between Organisms
30.6K
Genetic transfer occurs when genetic information is passed from one organism to another. It occurs via two mechanisms: vertical gene transfer and horizontal gene transfer. Vertical gene transfer occurs when genetic information is transferred from one generation to the next, which happens much more frequently than horizontal gene transfer. Both sexual and asexual reproduction are forms of vertical gene transfer, where one or more organisms pass some or all of their genome onto their progeny.
30.6K
Factors Influencing Attraction V: Social Skills
736
Social skills play a crucial role in shaping interpersonal interactions and enhancing individuals' ability to navigate various social environments successfully. These skills contribute to personal and professional success, influencing how others perceive and treat individuals. High social skills provide distinct advantages in numerous settings, including romantic relationships, politics, and legal proceedings. In courtroom settings, for instance, defendants who exhibit strong social skills are...
736


