母亲殖民,围产期暴露和新生儿获得耐药性肠道细菌
Leena B Mithal1,2, Alima Sajwani1, Abigail Aron1
1Ann and Robert H. Lurie Children's Hospital, Chicago, IL, USA.
Open forum infectious diseases
|January 22, 2026
概括
耐素的肠道细菌 (AmpR-E) 和耐素的肠道细菌 (CefR-E) 在芝加哥的孕妇和新生儿中很常见. 发生CefR-E的围产期传播,突出了对这些耐药细菌进一步研究的需要.
科学领域:
- 微生物学 微生物学
- 传染性疾病 传染性疾病
- 基因组学就是基因组学.
背景情况:
- 肠道细菌的抗生素耐药性,特别是抗素耐药性 (AmpR-E) 和 ceftriaxone耐药性 (CefR-E),构成了全球卫生挑战.
- 围产期传播CefR-E菌株与增加的死亡率,发病率和医疗保健成本有关.
- 了解这些耐药细菌的殖民率和遗传特征在生育父母婴儿双中至关重要.
研究的目的:
- 在芝加哥健康分娩的父母婴儿二合体中估计AmpR-E和CefR-E的肠道殖民率.
- 为了研究这些二的CefR-E分离物的遗传特征.
- 评估CefR-E.的围产期传播情况.
主要方法:
- 在芝加哥两家医院招收预期阴道分娩的孕妇.
- 采集母亲的阴道/直肠拭子和婴儿便样本,用于抗药性查.
- 用于基因分析的CEFR-E分离物的全基因组测序.
主要成果:
- 观察到高殖民率:91%的父母AmpR-E,76%的婴儿AmpR-E,12%的父母CefR-E和7%的婴儿CefR-E.
- 据估计,CefR-E的围产期传播率为17%.
- 种族与父母的CefR-E殖民性有关,而父母的年龄和婴儿母乳营养与婴儿AmpR-E殖民性的下降有关.
结论:
- 美国有很大比例的健康孕妇被AmpR-E和CefR-E殖民,超过了高收入国家之前的报道.
- 肠杆菌表现出高效的围产期传播,显著的百分比的婴儿在生命的第一个星期内获得CefR-E.
- 这些发现强调了监测抗生素耐药性细菌在围产期的重要性.
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