尿中性粒细胞调解剂作为预测性生物标志物,用于成人严重登革热
Andrew Teo1,2,3, Po Ying Chia1,3,4, Sharlene Ho5
1Department of Respiratory and Infectious Diseaes, Lee Kong Chian School of Medicine,Nanyang Technological University, Singapore, Singapore.
Open forum infectious diseases
|January 22, 2026
概括
尿中性粒细胞凝酶相关的利波卡林和可溶性尿酶等离子体激活受体显示出作为预测发烧期严重登革热的非侵入性生物标志物的承诺. 这些发现可能有助于对登革热患者的早期风险分层.
科学领域:
- 传染性疾病 传染性疾病
- 生物标志物发现发现
- 临床诊断 临床诊断 临床诊断
背景情况:
- 登革热对全球健康构成重大威胁,需要可靠的预后生物标志物来早期检测严重疾病.
- 当前严重登革热的诊断方法往往缺乏特异性或需要侵入性手术.
研究的目的:
- 评估尿中性粒细胞凝酶相关性脂卡林 (NGAL) 和可溶性尿激酶激活体受体 (suPAR) 作为预测发烧期严重登革热的非侵入性生物标志物的有效性.
- 评估这些生物标志物的诊断性能,以区分严重和不严重的登革热病例.
主要方法:
- 在怀疑登革热感染的发烧患者中,对尿中NGAL和suPAR水平的前性评估.
- 对接收器运行特征 (ROC) 曲线的分析,以确定生物标志物性能曲线下的面积 (AUC).
- 生物标志物性能与严重登革热分类的既定标准的比较.
主要成果:
- 尿液NGAL在预测严重登革热方面表现出高诊断准确度,AUC为0.88.
- 尿液suPAR也显示出显著的预测价值,严重登革热的AUC为0.79.
- 这两种生物标志物在区分发烧期的严重登革热结局方面均有效.
结论:
- 尿路NGAL和suPAR是早期预测严重登革热的有希望的非侵入性生物标志物.
- 这些尿路生物标记物的使用在临床环境中为风险分层提供了实际优势.
- 需要在更大的队列中进一步验证,以确定它们在常规登革热管理中的作用.
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