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尿道查的UF-5000 Atyp.C参数:检测非典型细胞和包含性细胞的影响

Yuki Fujiwara¹, Yuzuru Takei², Hiroto Nakazawa²

¹Department of Integrative Physiology, Graduate School of Medicine, Gunma University, Maebashi, Japan.

Practical laboratory medicine

|January 22, 2026

概括

在UF-5000分析仪.

科学领域:

临床化学和尿液分析.
诊断细胞学.
医学实验室技术.

背景情况:

尿沉积物检查对于检测异常泌尿道细胞至关重要,但取决于操作者.
自动化尿液分析仪提供细胞组件的客观量化.
UF-5000的非典型细胞 (Atyp.C) 参数量化了富含核酸的粒子.

研究的目的:

评估UF-5000的Atyp.C参数与非典型泌尿道细胞和细胞内含细胞 (ICIB) 的存在之间的关系.
评估Atyp.C参数的查性能,以检测这些异常细胞.

主要方法:

使用UF-5000自动化尿液分析仪分析了264个尿样.
通过手动显微镜识别了非典型和ICIB阳性细胞.
通过ROC分析和灵敏度/特异性计算,对不同组的Atyp.C值进行比较,并评估诊断性能.

主要成果:

在对非典型细胞阳性的样本中,atyp.C值显著更高 (p < 0.001).
在非典型细胞和ICIB阳性之间观察到适度的一致性 (科恩 κ = 0.534).
当包括ICIB阳性样本时,ROC分析显示AUC为0.895,截止值为0.3细胞/μL,提供最佳灵敏度 (85.2%) 和特异性 (68.2%).

结论:

UF-5000 Atyp.C参数有效检测核酸含量增加的细胞,包括非典型和ICIB阳性细胞.
将ICIB纳入诊断标准提高了查的敏感性,使Atyp.C成为一种有价值的尿液分析工具.
将自动化分析与手动显微镜相结合,可以提高非典型细胞检测的效率.

关键词:

不典型的细胞细胞.流动细胞计量流动细胞计量细胞内细胞质内含入载体 (ICIB) 细胞在UF-5000中使用.尿液沉积物的尿液沉积物尿路细胞癌是什么意思

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