与骨质疏松症之间的关联:利用NHANES数据进行的跨部门研究
He Liu1, Yilong Hu2, Jianmin Liu1
1Department of Orthopedics, Nanjing Tongren Hospital Affiliated to Medical College of Southeast University, Nanjing, China.
Dose-response : a publication of International Hormesis Society
|January 22, 2026
概括
血中的高含量与骨质疏松症风险增加有关,特别是在女性和非西班牙裔黑人个体中. 这表明环境中的暴露可能会影响骨健康,需要更新安全标准.
科学领域:
- 环境健康 环境健康
- 骨的新陈代谢 骨的新陈代谢
- 毒理学 毒理学 毒理学
背景情况:
- 骨质疏松症是一个重大的公共卫生挑战.
- 了解环境暴露,如,对于预防骨质疏松症至关重要.
- 关于环境中低至中度暴露及其对健康的影响的知识存在差距.
研究的目的:
- 调查血液中的含量与美国人口骨质疏松症患病率之间的关联.
- 探索剂量-反应关系,并确定易受伤害的子组.
- 解决了解环境暴露影响的关键差距.
主要方法:
- 来自2017-2020年国家健康和营养检查调查 (NHANES) 的2901名成人的分析.
- 血液中的含量分为四分位数的分类.
- 应用多变量逻辑回归,受限立方线 (RCS) 和Boruta算法用于关联和剂量反应分析,调整共变量.
主要成果:
- 血液中最高的四分位数与骨质疏松症患病率增加32%有关.
- 观察到一种非线性剂量-反应关系,其拐点为0.12μg/L.
- 在女性,非西班牙裔黑人个人和那些接受了9至11年的教育的人群中,注意到了显著的效果修改.
结论:
- 低于当前安全门的环境含量可能与更高的骨质疏松症患病率有关.
- 女性和非西班牙裔黑人群体似乎特别容易受到对骨健康的影响.
- 这些发现支持修订生物监测标准,并实施针对弱势群体的有针对性的查.
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