动脉支架移植后与缩相关的因素在闭细胞支架和开细胞支架之间有所不同
Yayue Liu1, Yujie Sun2, Guangwen Li2
1Qingdao University, Qingdao, Shandong, China.
Frontiers in neurology
|January 22, 2026
概括
在 carotid 动脉支架 (CAS) 后,支架内静止 (ISR) 的风险因素因支架设计而异. 症状性狭窄是闭细胞支架 (CCS) 的关键,而残留性狭窄和糖尿病则是开细胞支架 (OCS) 的关键.
科学领域:
- 血管外科 血管外科
- 干预心脏病学 干预心脏病学
- 生物医学工程 生物医学工程
背景情况:
- 在 carotid 动脉支架 (CAS) 之后的 stent 静止 (ISR) 是一个重大问题.
- 只有有限的研究比较了闭细胞支架 (CCS) 和开细胞支架 (OCS) 之间的ISR风险因素.
- 支架设计可能会影响ISR和相关风险因素的发展.
研究的目的:
- 为了比较CCS和OCS队列之间的ISR发生率和临床结果.
- 在CAS中根据支架设计识别和对比ISR相关的风险因素.
- 调查CCS和OCS之间ISR风险概况的潜在差异.
主要方法:
- 从2020年至2023年对257个CAS程序 (129个CCS,128个OCS) 的回顾性分析.
- 随访持续时间至少6个月,中位数为15个月.
- 通过CTA/DSA定义的ISR峰值缩速度>300cm/s或狭窄率≥50%;使用单变量和多变量Cox回归分析的风险因素.
主要成果:
- 在CCS和OCS组之间,整体ISR率没有显著差异 (p=0.073).
- 与OCS相比,CCS组的术前狭窄性更大,扩张后狭窄性更大,残留狭窄性更低 (p<0.05).
- 独立的ISR预测因素有所不同:CCS的症状性动脉样狭窄 (p=0.038),OCS的残留狭窄严重程度和糖尿病 (p<0.05).
结论:
- 虽然整体ISR率相似,但CAS后ISR的独立风险因素与支架设计有很大差异.
- 症状性动脉样硬化狭窄是CCS中ISR的一个关键预测因素.
- 残留狭窄症的严重程度和糖尿病是OCS中ISR的重要预测因素.
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