低维生素D水平与儿科骨折患者的愈合时间延长有关
Michael Guyot1, William Ross1, Catalina Baez2
1Department of Orthopaedic Surgery, College of Medicine, University of Florida, Gainesville, FL, USA.
Journal of the Pediatric Orthopaedic Society of North America
|January 22, 2026
概括
儿童维生素D水平较低与骨折愈合时间较长有关,特别是在下肢和手术后. 这强调了评估儿科骨折患者的维生素D状况的重要性,这些患者经历了延迟恢复.
科学领域:
- 整形外科 整形外科 整形外科
- 儿科医学 儿科医学
- 内分泌学 在内分泌学.
背景情况:
- 维生素D对骨健康和吸收至关重要.
- 以前的研究集中在成人骨折的预防,留下儿科骨折愈合未经探索.
- 这项研究研究了维生素D水平与儿科骨折的愈合时间之间的联系.
研究的目的:
- 调查低维生素D水平与儿科骨折中延长愈合时间之间的相关性.
- 在儿科患者群体中确定特定的患者群体,由于维生素D缺乏,他们可能更容易受到延迟愈合的影响.
- 为了向临床实践提供有关儿童骨折维生素D评估的信息.
主要方法:
- 对患有四肢骨折的儿科患者 (0-17岁) 的回顾性评估.
- 收集了有关人口统计,伤害细节,治疗,结果和维生素D水平 (正常>30.0 ng/mL,低≤29.9 ng/mL) 的数据.
- 该研究于2015年1月至2022年5月期间在美国东南部的一个机构进行.
主要成果:
- 61.4%的患者的维生素D水平较低.
- 低维生素D与显著更长的临床和放射治疗时间相关 (P=.019,P=.001).
- 在下肢骨折和需要手术的患者中,延长愈合更为明显.
结论:
- 低维生素D水平与儿科骨折中愈合延迟有关.
- 儿科整形外科医生应考虑在长时间愈合的患者中对维生素D进行评估.
- 早期评估和补充可能会改善维生素D不足的儿科骨折患者的结果.
相关概念视频
Pharmacokinetics in Pediatric Patients: Drug Excretion
214
In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
214
Pharmacokinetics in Pediatric Patients: Drug Distribution
269
Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
269
Pharmacokinetics in Pediatric Patients: Drug Metabolism
198
In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
198
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption
260
Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
260
Vitamins
2.3K
Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced...
2.3K
Mineral, Vitamin and Water Absorption
1.5K
Electrolytes are essential minerals and ions primarily obtained from the diet and absorbed through the gastrointestinal tract. Most electrolytes are absorbed in the small intestine. While the absorption of iron and calcium primarily occurs in the duodenum, calcium is also absorbed in the jejunum and ileum. In these regions, passive diffusion contributes to its absorption alongside active transport mechanisms in the duodenum. These ions can exit the enterocytes through specialized active...
1.5K


