绝经前期作为肥胖引起的敏感时期:对心血管风险升高的贡献
Margot E Manning1, Sara L Stockman2, Markella V Zanni2
1Internal Medicine Residency Program, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA 02114.
American journal of preventive cardiology
|January 22, 2026
概括
在服用抗精神病药物时,经历显著体重增加的绝经前妇女可能具有较高的代谢敏感性. 在这个更年期过渡期间,临床医生应该谨慎地开处方肥胖药物.
科学领域:
- 内分泌学 在内分泌学.
- 妇女健康 妇女健康
- 药理学 药理学是指药理学的学科.
背景情况:
- 绝经前期加速了动脉样硬化心血管疾病 (CVD) 的风险,部分原因是身体脂肪的再分配.
- 在更年期期间,女性可能会增加内脏脂肪组织并失去关节脂肪,增加心血管疾病风险因素.
- 这一案例考察了一个经更年期前妇女开始服用抗精神病药物并产生肥胖效应的不成比例体重增加.
研究的目的:
- 呈现一个显著的体重增加和脂肪再分配的案例,在一个更年期前妇女开始长效注射抗精神病药物.
- 为了突出药物诱导的体重增加的潜力,在绝经前期.
- 为了强调这个生命阶段代谢敏感度的提高.
主要方法:
- 一个46岁妇女的病例报告,患有精神分裂情绪障碍和甲状腺功能低下症.
- 身体检查显示,体重增加显著,脂肪分布偏心.
- 实验室测试评估了甲状腺功能,更年期状态和皮质醇水平.
主要成果:
- 患者体重增加了9.2公斤,转变为超重的BMI与中心脂肪分布.
- 停用了抗精神病药物,但尽管改变了生活方式,但没有实现显著的体重减轻.
- 荷尔蒙评估表明经更年期,甲状腺和皮质醇水平正常.
结论:
- 绝经前的因素可能会加剧药物诱导的体重增加,导致中心脂肪分布.
- 代谢记忆可以阻碍减肥,强调更年期是对药物效应敏感度增加的时期.
- 临床医生必须对绝经前患者的肥胖药物保持谨慎,监测心脏代谢风险并支持改变生活方式.
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