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Updated: Jan 23, 2026

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在脂肪衍生干细胞和富血小板血的卵巢内给药后的第一个活产儿
Zaher Merhi1,2,3, Bhavika Garg4, Jessica Haroun3
1Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Albert Einstein College of Medicine Bronx, NY, USA.
American journal of stem cells
|January 22, 2026
概括
两名45岁以上的妇女使用一种新的脂肪纳米脂肪与干细胞和富含血小板血的卵巢内注射实现了活产. 这种再生疗法为寻求遗传相关子女的卵巢储备减少的妇女提供了希望.
科学领域:
- 生殖医学 生殖医学
- 再生医学是一种再生医学.
- 干细胞疗法是一种干细胞疗法.
背景情况:
- 先进的孕产妇年龄 (45岁以上) 对生育提出了重大挑战,通常与卵巢储备减少有关.
- 试管婴儿 (IVF) 和其他辅助生殖技术 (ART) 在老年妇女中成功率有限.
- 之前的生育治疗,包括最小刺激的试管婴儿,对这两名患者都没有成功.
研究的目的:
- 在45岁及以上的女性中,评估一种结合脂肪基干细胞 (ADSC) 和富血小板血 (PRP) 的新型卵巢内再生疗法的疗效.
- 在卵巢储量减少和不孕症患者中记录这种治疗导致的活产.
- 探索符合监管指导方针的最小操纵脂肪组织方法.
主要方法:
- 机械加工的脂肪纳米脂肪 (富含ADSCs) 与自身的PRP相结合的卵巢内给药.
- 治疗适用于两名45岁和46岁的女性,她们有不孕症史和失败的ART周期.
- 脂肪加工方法避免了酶处理,以符合FDA的最小操纵指南.
主要成果:
- 案例1:一名46岁的女性在治疗后六个月自然怀孕,并在47岁时分娩了一个健康的婴儿.
- 案例2:一名45岁的妇女通过冷胚胎移植实现了活产,该胚胎是在治疗后三个月产生的欧体胚胎.
- 两位患者均有卵巢储量减少和/或子宫内膜异位症,此前多次试图试管婴儿并未成功.
结论:
- 结合性卵巢内ADSC-纳米脂肪和PRP注射可能是45岁以上女性卵巢储备减少的有前途的再生治疗方法.
- 这种方法促进了自然受孕和成功的胚胎移植,在研究的病例中导致活产.
- 需要进一步的受控研究来证实长期的安全性,疗效和最佳的患者选择这种新疗法.
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