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病例报告:复发性全身性红斑狼治疗与双重rituximab和anifrolumab治疗
Sunnie Lee1, Janet Choi2, Steven Benitez3
1Department of Medicine, Rutgers New Jersey Medical School, Newark, NJ, United States.
Frontiers in medicine
|January 22, 2026
概括
这项案例研究突出了对耐火性系统性红斑狼 (SLE) 双重生物治疗的成功使用,该治疗既具有皮肤症状,也具有神经症状. 结合利图西马布和阿尼弗罗卢马布有效地管理了严重的SLE表现.
科学领域:
- 免疫学 免疫学 免疫学
- 类风湿病学 类风湿病学
- 神经学 神经学
背景情况:
- 系统性红斑狼 (SLE) 管理通常涉及生物单一疗法.
- 有限的数据存在于SLE的双重生物疗法的疗效和安全性.
- 这个病例涉及一个患有SLE,罗威尔综合征 (RS) 和莫亚莫亚病的患者.
研究的目的:
- 报告一种具有皮肤和神经参与的耐火性SLE病例.
- 在这个复杂的病例中评估双重生物疗法 (rituximab和anifrolumab) 的疗效和安全性.
主要方法:
- 这位患者最初接受了Anifrolumab的治疗.
- 由于怀疑中枢神经系统狼和莫亚莫亚综合征的进展,阿尼弗罗卢马布的治疗被停止,治疗转换为皮质类固醇和利图西马布.
- 后来,阿尼弗罗卢马布与瑞图西马布一起重新引入治疗耐火性皮肤症状.
主要成果:
- 最初使用Rituximab的治疗导致神经系统的改善.
- 随后与rituximab和anifrolumab的双重治疗导致皮肤症状 (罗威尔综合征) 显著改善.
- 这代表了首次报告的成功双重生物疗法与rituximab和anifrolumab对于耐火性SLE与多器官参与的成功案例.
结论:
- 双重生物疗法与rituximab和anifrolumab可以有效地管理耐火性SLE与皮肤和神经表现.
- 这种治疗方法可能为复杂的SLE病例提供可行的选择,这些病例对单一治疗没有反应.
- 需要进一步的研究来探索SLE中双重生物策略的更广泛的应用和长期结果.
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