饮食模式,体力活动和尿路疾病的风险:两个样本的门德尔随机化分析分析
Chenxuan Zhao1, Fengying Deng1, Junlan Qiu2
1Institute for Fetology, The First Affiliated Hospital of Soochow University Suzhou 215006, Jiangsu, P. R. China.
American journal of clinical and experimental immunology
|January 22, 2026
概括
健康饮食,包括水果,坚果和鱼类,以及像徒步旅行这样的定期体育活动,可以显著降低患脏疾病的风险. 然而,休时间的屏幕时间是这些情况的风险因素.
科学领域:
- 遗传学和流行病学
- 脏和泌尿器官健康
- 营养科学 营养科学
背景情况:
- 生活方式因素 (饮食,体育活动) 和脏/尿路疾病之间存在确定的关联.
- 有限的研究已经利用门德尔的随机化来确定这些生活方式因素和脏/泌尿病之间的因果关系.
研究的目的:
- 使用孟德尔随机化研究各种饮食模式,体育活动模式和脏/泌尿疾病的频谱之间的因果关系.
- 通过改变生活方式,为预防脏和尿路疾病提供基于证据的建议.
主要方法:
- 采用孟德尔随机化 (MR) 分析,主要使用逆方差加权方法.
- 利用来自BioBank,FinnGen和NHGRI-EBI数据库的大规模遗传和表型数据.
- 进行异质性和多重性分析,以确保研究结果的稳定性和有效性.
主要成果:
- 特定的饮食习惯,如消费大豆制糖,新鲜水果,,坚果,瘦鱼和脂肪鱼,与各种疾病的风险降低有关,包括慢性脏病 (CKD),良性上腺瘤,免疫球蛋白A脏病 (IgA-N) 和2型糖尿病 (T2D) 脏病.
- 娱乐性徒步旅行,游泳,骑自行车,健身和保龄球等体力活动与IgA-N和T2D炎有相反的关联.
- 休屏幕时间 (LST) 成为脏/泌尿器官异常的风险因素.
结论:
- 富含水果,坚果和鱼类的饮食,加上增加步行等体育活动,可以预防慢性脏疾病,包括慢性功能不足,衰竭,T2D脏病和IgA脏病.
- 这项研究增强了对饮食和体育活动对脏/尿路健康的影响的理解.
- 研究结果提供了切实可行的策略,以减少这些流行疾病的发病率.
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