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针对腹腔大动脉动脉瘤的向炎症微环境重塑和NIR-II光热疗法
Yijun Liu1, Peng Qiu1, Huifang Hao2
1Department of Vascular Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Materials today. Bio
|January 22, 2026
概括
一个新的纳米平台通过结合光热疗法和炎症抑制来有效治疗腹腔大动脉动脉瘤 (AAA). 这种有针对性的方法减少了AAA的进展,并保护了血管健康.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术 纳米技术
- 心血管研究研究心血管研究
背景情况:
- 腹腔大动脉瘤 (AAA) 是一种严重的血管疾病,死亡率高,没有有效的早期医疗治疗.
- 炎症微环境在AAA病变发生过程中起着至关重要的作用,使其重塑成为关键的治疗目标.
研究的目的:
- 设计和评估一个多功能纳米平台 (CS@MBR) 的目标AAA治疗.
- 研究近红外II (NIR-II) 光热疗法 (PTT) 和NLRP3炎症酶抑制对AAA的联合作用.
- 在小鼠AAA模型中评估纳米平台的准能力和治疗疗效.
主要方法:
- 一个纳米平台的制造包括一个Cu9S8核心,封装的NLRP3抑制剂 (MCC950,Belnacasan) 和一个cRGDfK向.
- 在实验室评估纳米平台对炎细胞激活,巨细胞两极分化和血管光滑肌肉细胞表型的影响.
- 在NIR-II照射后,在NIR-II诱导的小鼠AAA模型中,对纳米平台积累,AAA抑制和炎症微环境调节的体内评估.
主要成果:
- 在实验室中,CS@MBR纳米平台证明有效抑制NLRP3炎症酶激活和促炎性巨细胞极化.
- 在体内研究表明,CS@MBR在动脉瘤部位的集是有针对性的.
- 用CS@MBR进行NIR-II辐射显著抑制了AAA的发展,保护了弹性纤维,并恢复了炎症平衡.
结论:
- 多功能纳米平台CS@MBR为腹腔大动脉动脉瘤提供了一个有希望的有针对性的治疗策略.
- 这种方法有效地结合了PTT和炎症酶抑制来对抗AAA.
- 这项研究强调了纳米疗法在治疗AAA和其他炎症性血管疾病方面的潜力.
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