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Updated: Jan 23, 2026

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PD-L2 景观与结果的相关性:免疫学分析

Anannya Patwari¹, Daisuke Nishizaki², Taylor Jensen³

¹MCW Cancer Center and Genomic Sciences and Precision Medicine Center, Medical College of Wisconsin, Milwaukee, WI, United States.

JCO oncology advances

|January 22, 2026

概括

高编程死亡连接体2 (PD-L2) 表达与接受免疫治疗的患者的更好的结果有关. 这一发现突显了PD-L2在癌症免疫逃脱和治疗反应中的作用.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
基因组学就是基因组学.

背景情况:

编程死亡配体1 (PD-L1) 和PD-L2是通过与PD-1受体相互作用而在免疫逃避中的关键配体.
虽然PD-L1得到了充分的研究,但PD-L2在免疫检查点阻塞疗效中的作用仍然不太清楚.
抗PD-L1疗法可能会影响PD-L2表达PD-1轴阻塞的完整性,并影响抗PD-1药物的活性.

研究的目的:

为了研究PD-L2在各种癌症类型中的转录基因表达.
探索PD-L2表达和免疫调节变量之间的关联.
确定PD-L2表达在患有晚期/转移性癌症的患者的预后意义.

主要方法:

在514名患者的泛癌队列中分析PD-L2转录组表达.
PD-L2表达与PD-L1,PD-1,CD4,TIM-3和瘤突变负担 (TMB) 等免疫调节因子的相关性.
评估PD-L2表达作为总生存期 (OS) 和无进展生存期 (PFS) 的预后标记在免疫治疗和未治疗患者队列中.

主要成果:

在19.5%的患者中观察到高PD-L2表达 (≥75百分位),并因瘤类型而异,在乳腺癌中更为常见.
高的PD-L2与高的PD-L1,PD-1,CD4,TIM-3RNA水平以及高的TMB (≥10个突变/兆基) 有显著的相关性.
在接受免疫治疗的患者中 (n=217),高PD-L2预测了更长的生存期 (p=0.02),但没有PFS;在非免疫治疗患者中没有发现预后值 (n=272).

结论:

高的PD-L2转录水平与有利的免疫特征有关,包括PD-L1,PD-1,CD4,TIM-3的高表达,以及高的TMB.
增加PD-L2表达与接受免疫检查点阻塞治疗的患者的整体存活率改善相关.
PD-L2值得进一步研究,因为它是预测免疫治疗反应的潜在生物标志物.

关键词:

免疫检查点抑制剂免疫检查点抑制剂免疫治疗是一种免疫疗法.新生体新生体新生体精准医学是一门精准的医学.编程细胞死亡 1 带 2 蛋白质

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