鲁通过延长凝血路径时间,在人体血液样本中表现出体内抗凝剂活性
Anjan Palikhey1, Laxmi Zaiswal2, Amit Kumar Shrivastava1
1Department of Pharmacology, Universal College of Medical Sciences, Bhairahawa, Nepal.
Global advances in integrative medicine and health
|January 22, 2026
概括
植物类黄胺的鲁丁在人体血液样本中通过延长凝血时间,前列血时间和激活的部分血栓塑时间,表现出显著的体外抗凝剂作用.
科学领域:
- 生物化学 生化学
- 药理学 药理学是指药理学的学科.
- 血液学 血液学 血液学
背景情况:
- 鲁丁是一种在已知生物活动的植物中发现的黄类化合物.
- 它在血液凝固参数上的体外抗凝剂作用需要进一步描述.
研究的目的:
- 为了研究人体血液中鲁丁的体外抗凝活性.
- 为了测量凝血时间 (CT),前列血时间 (PT) 和激活的部分血栓塑时间 (aPTT) 的变化,在不同的鲁丁度下.
主要方法:
- 人类血液样本用1-6毫克/毫升的度处理了鲁丁.
- 进行了标准CT,PT和aPTT测定.
- 酸盐缓冲盐水 (PBS) 和肝素作为对照.
主要成果:
- 与PBS相比,Rutin显著增加了CT,PT和aPTT,以度依赖的方式.
- 最显著的抗凝剂作用是在4和6毫克/毫升 (P <0.05) 的鲁丁度下观察到的.
- 在6mg/mL时,CT,PT和aPTT分别增加到11.42±1.11分钟,21.33±3.28秒和57.20±9.31秒.
结论:
- 鲁丁在体外表现出显著的抗凝剂活性.
- 这些发现支持了鲁丁作为天然抗凝剂的潜力.
相关概念视频
Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants
2.2K
Oral anticoagulants are vital tools in preventing and treating blood clotting disorders. This diverse class of medications can be categorized as vitamin K antagonists, exemplified by warfarin, and direct thrombin inhibitors (DTIs), such as dabigatran, as well as factor Xa inhibitors, including rivaroxaban.
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
2.2K
Coagulation
1.3K
Colloidal solids are solid particles suspended in solution. They are usually negatively charged, attracting a compact primary layer of positively charged ions, which attract more counterions to form an electrical double layer. Electrostatic repulsion between the charged double layers prevents the particles from colliding, stabilizing the colloids. These solids are often undesirable because they can contain toxins that are difficult to remove. Coagulation is a technique that helps aggregate and...
1.3K
Coagulation
9.8K
The coagulation phase is a critical part of the body's process to prevent blood loss following injury to blood vessels. It involves chemical reactions that form a clot to seal the injured area. The clotting process begins shortly after injury, within 15-20 seconds for severe damage and 1-2 minutes for minor injuries.
During the coagulation phase, clotting factors, or procoagulants, play a vital role in initiating and progressing the coagulation cascade. This cascade is a series of reactions...
During the coagulation phase, clotting factors, or procoagulants, play a vital role in initiating and progressing the coagulation cascade. This cascade is a series of reactions...
9.8K
Sampling Continuous Time Signal
704
In signal processing, a continuous-time signal can be sampled using an impulse-train sampling technique, followed by the zero-order hold method. Impulse-train sampling involves the use of a periodic impulse train, which consists of a series of delta functions spaced at regular intervals determined by the sampling period. When a continuous-time signal is multiplied by this impulse train, it generates impulses with amplitudes corresponding to the signal's values at the sampling points.
In the...
In the...
704
Anticoagulant Drugs: Low-Molecular-Weight Heparins
1.7K
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
1.7K
C4 Pathway and CAM
48.9K
Most plants use the C3 pathway for carbon fixation. However, some plants, such as sugar cane, corn, and cacti that grow in hot conditions, use alternative pathways to fix carbon and conserve energy loss due to photorespiration. Photorespiration is the process that occurs when the oxygen concentration is high. Under such conditions, the rubisco enzyme in the Calvin cycle binds O2 instead of CO2, which halts photosynthesis and consumes energy.
C4 Pathway
The C4 pathway is used by plants such as...
C4 Pathway
The C4 pathway is used by plants such as...
48.9K


