在两个纵向队列中,脑年龄轨迹和中风后的认知
Gisle Berg Helland1,2,3, Håkon Ihle-Hansen2, Anne Hege Aamodt1,4,5
1Department of Neurology, Oslo University Hospital, 0424 Oslo, Norway.
Brain communications
|January 22, 2026
概括
脑衰老在中风后显著加快,这表明生物衰老的速度更快. 在中风发作时大脑年龄较高预测了更糟糕的长期认知功能,这表明它作为预后生物标志物的实用性.
科学领域:
- 神经成像是一种神经成像.
- 脑卒中研究 脑卒中研究
- 衰老研究研究 衰老研究
背景情况:
- 大脑年龄是一个有前途的神经成像生物标志物,用于生物衰老.
- 脑衰老的长期轨迹和中风后的认知预测值尚不清楚.
研究的目的:
- 在中风后8年内描述大脑衰老的轨迹.
- 评估大脑年龄对长期认知结果的预测价值.
主要方法:
- 使用T1加权MRI对缺血性中风患者 (<65岁) 的纵向分析,使用T1加权MRI长达8年.
- 通过深度学习估计的大脑年龄;计算大脑预测年龄差异 (Brain-PAD).
- 线性混合效应模型用于大脑-PAD轨迹; 线性回归用于认知表现 (MoCA).
主要成果:
- 随着时间的推移,大脑PAD显著增加 (0.6/年),表明中风后大脑衰老加速.
- 观察到加速衰老在半球的ipsilesional但不是 contralesional.
- 较高的急性大脑年龄预测了较低的长期MoCA得分,独立于时间年龄.
结论:
- 脑卒中与加速的大脑衰老有关.
- 大脑年龄是中风后长期认知结果的重要预测因素.
- 大脑年龄可以作为认知预后的早期生物标志物.
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