扩散曲解成像检测到粉素阳性MCI患者的皮质微结构变化
Rune B Nielsen1, Peter Parbo2, Rola Ismail3
1Center of Functionally Integrative Neuroscience, Aarhus University, Aarhus, Denmark.
Frontiers in dementia
|January 22, 2026
概括
扩散曲解成像 (DKI) 检测轻度认知障碍 (MCI) 的早期大脑变化,与粉样β (Aβ) 斑块相关. 这种方法在显著缩发生之前有望识别阿尔茨海默病 (AD).
科学领域:
- 神经成像是一种神经成像.
- 生物标志物 生物标志物
- 阿尔茨海默氏症疾病研究研究
背景情况:
- 阿尔茨海默氏病 (AD) 标志着早期的粉样β (Aβ) 斑块和病理,先于神经退行和认知衰退.
- 在缩之前检测与Aβ沉积相关的微观结构性大脑变化对于早期AD诊断和干预至关重要.
研究的目的:
- 调查扩散性皮质损伤成像 (DKI) 是否可以检测轻度认知障碍 (MCI) 个体中与Aβ病理相关的灰质 (GM) 的早期微观结构变化.
主要方法:
- 利用DKI衍生的指标,平均度 (MK) 和平均扩散度 (MD),评估67名参与者的皮层和皮层下微观结构 (23个认知正常[CN],44个MCI).
- 使用11C-PiB PET成像量化Aβ负担,并评估皮质缩,海马体积和白质超强度 (WMH).
主要成果:
- 与CN和Aβ阴性MCI组相比,Aβ阳性MCI患者表现出显著升高的皮质MK,特别是在左侧叶和右前皮,与CN和Aβ阴性MCI组相比.
- 皮层MK与皮和皮中的Aβ负担正相关,独立于皮层缩.
- 平均扩散度 (MD) 与Aβ的关联较弱,并且受年龄的影响更大;没有发现显著的皮质下MK或MD差异.
结论:
- 在Aβ阳性MCI患者中MK升高表明DKI能够在皮质缩发作之前检测与粉样蛋白病理相关的早期微观结构变化.
- 平均曲症 (MK) 显示出作为一种非侵入性生物标志物,用于识别预发性阿尔茨海默病和监测疾病进展.
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