对于再生医学而言,器官生物打印的进展
Xiang Wang1, Di Zhang1, Yogendra Pratap Singh2,3
1Center for Materials Synthetic Biology, Chinese Academy of Sciences Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
概括
三维 (3D) 生物打印为器官再生和移植提供了一个有前途的解决方案. 本综述涵盖了生物打印技术,材料和临床翻译的挑战.
科学领域:
- 再生医学是一种再生医学.
- 组织工程是组织工程.
- 生物技术是生物技术.
背景情况:
- 由于受伤,疾病或衰老造成的器官损伤是严重的健康挑战,原因是自然再生有限.
- 器官移植面临着供体短缺和免疫排斥,推动了寻求替代解决方案的需求.
- 三维 (3D) 生物打印正在成为组织工程和再生医学的关键技术.
研究的目的:
- 审查目前用于器官制造的3D生物打印技术的最新进展.
- 讨论生物打印固体器官的进展,包括心脏,肝脏,脏和胰腺.
- 确定生物打印器官临床翻译和大规模生产的关键挑战和未来方向.
主要方法:
- 审查最先进的生物打印技术.
- 专注于生物墨水和细胞类型选择策略.
- 分析固体器官生物打印方面的进展,强调血管化和细胞集成.
主要成果:
- 探索各种生物打印技术及其应用.
- 讨论生物打印复杂固体器官的进展情况.
- 识别功能性器官发育的关键因素,如血管化和细胞集成.
结论:
- 3D生物打印对按需生成器官具有重大前景,解决了供体短缺和免疫排斥问题.
- 血管化和成功的细胞集成对于生物打印器官的活力和功能至关重要.
- 克服技术,材料和临床翻译方面的挑战对于生物打印器官的广泛采用至关重要.
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