相关实验视频
Updated: Jan 23, 2026
08:07
Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
Published on: April 12, 2019
7.6K
奥兰沙平通过SAA1基因和与细胞外矩阵相关的途径通过口服肠球菌影响骨形成
Hui Yuan1, Min-Yuan Wang1,2, Rui-Xi Liu1
1Department of Stomatology, Hunan Provincial Engineering Research Center of Digital Oral and Maxillofacial Defect Repair, Hunan Provincial Clinical Research Center for Oral Diseases, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Frontiers in cellular and infection microbiology
|January 22, 2026
概括
在精神分裂症中使用 olanzapine 治疗可能会破坏口腔细菌,导致骨质减少. 与SAA1基因表达相关的Enterococcus增加似乎抑制了骨形成和原蛋白的产生.
科学领域:
- 药理学 药理学是指药理学的学科.
- 微生物学 微生物学
- 骨的新陈代谢 骨的新陈代谢
背景情况:
- 奥兰沙平是一种常见的精神分裂症治疗方法,但其对骨代谢的影响尚不清楚.
- 改变的肠道微生物群是药物诱导的骨代谢变化的潜在因素.
- 这项研究研究了 olanzapine 对精神分裂症的骨代谢和口腔微生物群的影响.
研究的目的:
- 为了探索 olanzapine 加剧异常骨代谢的假设.
- 为了研究 olanzapine,细菌失衡和精神分裂症患者的骨健康之间的联系.
主要方法:
- 奥兰扎因通过胃肠道给小鼠服用.
- 分析了膜骨组织和口腔微生物群的变化.
- 研究了特定细菌对骨质生成的影响.
主要成果:
- 奥兰zapine增加了Enterococcus的丰富性,与膜骨质量和I型原蛋白的减少相关.
- 杆菌脂铁醇酸 (LTA) 抑制了骨质分化,并上调了SAA1基因表达.
- 发现SAA1基因降低了COL1A1基因表达的调节,这表明了潜在的蛋白质相互作用.
结论:
- 奥兰沙平可能会增加口服菌,通过SAA1基因上调和细胞外矩阵通路潜在地抑制骨形成.
- 这些发现表明,基于微生物群的策略可以减轻骨并发症,并改善精神分裂症患者的口腔健康.
- 在clinicaltrials.gov注册的临床研究 (NCT06123897).
相关概念视频
01:42The Extracellular Matrix
88.3K
Overview
88.3K
01:29The Extracellular Matrix
12.0K
Overview
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
The extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse...
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
The extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse...
12.0K
01:18The Bone Matrix
5.5K
Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in...
5.5K
01:26Extracellular Matrix
5.2K
Unlike epithelial tissue, which is composed of cells closely packed with little or no extracellular space in between, connective tissue cells are dispersed in a matrix. This extracellular matrix (ECM) is composed of fibrous proteins like collagen, elastin, and fibronectin in a ground substance consisting of interstitial fluid, cell adhesion proteins, and proteoglycans. The proteoglycans form a gel-like material in the spaces between cells and provide hydration, buffering, binding, and force...
5.2K
01:24Bone Formation by Endochondral Ossification
8.6K
Bone formation, or ossification, begins around the sixth to seventh week of embryonic development. Most bones develop from a cartilaginous template through the process of endochondral ossification. Cartilage formation begins when clusters of mesenchymal cells differentiate into chondrocytes. These chondrocytes proliferate rapidly and secrete an extracellular matrix that becomes encased in a membrane called the perichondrium. The resulting cartilage model provides a template that resembles the...
8.6K
01:29Bone Formation by Intramembranous Ossification
10.4K
Intramembranous ossification is one of the two processes involved in the development of bones within an embryo. The flat bones of the face, most of the cranial bones, and the clavicles are formed via this process. During intramembranous ossification, the bones develop directly from sheets of undifferentiated mesenchymal connective tissue.
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into ...
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into ...
10.4K