用CMR绘制心肌过渡时间映射:一种新的微循环功能障碍的潜在参数,用于带有或没有心房动的过度肌痛性心脏病
Junlin Yang1, Yong Cheng1, Jinxiu Yang1
1Department of Radiology, The First Affiliated Hospital of Anhui Medical University, No.218 Jixi Road, Hefei, Anhui 230022, China.
European journal of radiology open
|January 22, 2026
概括
通过心血管磁共振 (CMR) 测量的肌心过渡时间 (MyoTT) 在高性心肌病 (HCM) 患者中升高,特别是那些心房动 (AF) 患者. 这个参数可能表明冠状动脉微血管功能障碍 (CMD) 在HCM.
科学领域:
- 心脏病学 心脏病学
- 医疗成像医学成像
- 生物物理学的生物物理.
背景情况:
- 增高性心肌病变 (HCM) 是一种遗传性心脏病,通常与冠状动脉微血管功能障碍 (CMD) 相关.
- 心房动 (AF) 是HCM患者的常见并发症,可能会使预后恶化.
- 目前在HCM中评估CMD的方法有局限性.
研究的目的:
- 使用心血管磁共振 (CMR) 作为HCM中CMD的潜在生物标志物,研究心肌过渡时间 (MyoTT).
- 评估MyoTT与HCM和AF状态的关联.
- 将MyoTT的诊断性能与其他CMR衍生的参数进行比较.
主要方法:
- 一组50名HCM患者和50名健康对照人接受了CMR扫描.
- 评估的参数包括心脏功能,原生T1,细胞外体积 (ECV),心肌菌株和MyoTT.
- 后勤回归和接收器运行特征 (ROC) 分析被用于评估关联和歧视性性能.
主要成果:
- 与对照组相比,HCM患者表现出显著改变的心脏功能,增加本源T1,ECV和MyoTT.
- MyoTT,本地T1,ECV和LV-GLS与HCM状态有显著的关联.
- 在HCM患者中,在AF患者中观察到较高的本源T1和MyoTT值.
- MyoTT在HCM (AUC=0.848) 和HCM内的AF (AUC=0.740) 中表现出良好的区分性能.
结论:
- 在HCM患者中,MyoTT升高,并且与AF的存在有关.
- MyoTT可以作为HCM中CMD的有价值的非侵入性成像标志物,特别是在AF的背景下.
- 需要进一步的研究来探索MyoTT在HCM管理中的临床影响.
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