Jove
Visualize
联系我们

相关概念视频

Long-term Depression01:05

Long-term Depression

33.2K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
33.2K
Long-term Depression01:03

Long-term Depression

3.1K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
3.1K
Seedless Vascular Plants03:24

Seedless Vascular Plants

66.7K
Seedless Vascular Plants Were the First Tall Plants on Earth
66.7K
Buoyancy and Stability for Submerged and Floating Bodies01:11

Buoyancy and Stability for Submerged and Floating Bodies

2.5K
In fluid mechanics, buoyancy and stability are key concepts for understanding the behavior of submerged and floating bodies. When a stationary body is fully or partially submerged in a fluid, the fluid exerts a force on the body known as the buoyant force. This force acts vertically upward through a point called the center of buoyancy, which is the center of the displaced fluid volume. According to Archimedes' principle, the magnitude of the buoyant force is equal to the weight of the fluid...
2.5K
Directional Terms01:14

Directional Terms

16.0K
Directional terms are essential for describing the relative locations of different body structures. For instance, an anatomist might describe one band of tissue as "inferior to" another, or a physician might describe a tumor as "superficial to" a deeper body structure. These terms often use comparative terms in pairs to trace out the relative locations of one body part to another or descriptions of body tissues like the deeper ones from superficially present with reference to...
16.0K
Long-term Potentiation01:25

Long-term Potentiation

3.5K
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
LTP can occur when...
3.5K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

HYPER-Net: Physics-Conditioned Self-Supervised Reconstruction for Fourier Light-Field Microscopy.

bioRxiv : the preprint server for biology·2026
Same author

Interkingdom signaling elicited by bacterial extracellular vesicles in human cystic fibrosis airway epithelium and neutrophils.

Frontiers in cellular and infection microbiology·2026
Same author

Efficacy of celastrol-supplemented diet in overweight and obese dogs: a 24-week randomized controlled trial.

Frontiers in veterinary science·2026
Same author

"<i>It was a new concept to talk about periods at the state capitol"</i>: a mixed methods implementation-as-usual evaluation of Georgia's menstrual health and hygiene policy.

Frontiers in reproductive health·2026
Same author

Substrate Exclusion Greenlights Physical Autocatalysis of Enzyme Activity in Membraneless Proto-Organelles.

Biomacromolecules·2025
Same author

Manipulation of the nucleoscaffold potentiates cellular reprogramming kinetics.

PNAS nexus·2025
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关实验视频

Updated: Jan 23, 2026

Efficient Vascularization of Kidney Organoids through Intracelomic Transplantation in Chicken Embryos
07:35

Efficient Vascularization of Kidney Organoids through Intracelomic Transplantation in Chicken Embryos

Published on: February 17, 2023

2.4K

自由漂浮的长期血管化介质细胞器官.

Alejandro de Janon1,2, Pranitha Kaza1, Kaede Yoshida1

  • 1W. H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, Atlanta, GA, USA.

iScience
|January 22, 2026
PubMed
概括

研究人员为长期研究组织血管化和癌症开发了血管化介质细胞器官 (VMOs). 这种新型号支持60天的稳定血管系统,为药物测试提供更高的复杂性和细胞活力.

关键词:
干细胞研究的研究.组织工程是组织工程.血管改造是指进行血管改造.

更多相关视频

Technique for Obtaining Mesenchymal Stem Cell from Adipose Tissue and Stromal Vascular Fraction Characterization in Long-Term Cryopreservation
05:57

Technique for Obtaining Mesenchymal Stem Cell from Adipose Tissue and Stromal Vascular Fraction Characterization in Long-Term Cryopreservation

Published on: December 30, 2021

3.9K
Author Spotlight: Improving Reproducibility in Vascular Organoids Using ROCK Inhibitors and Microwell Confinement
04:41

Author Spotlight: Improving Reproducibility in Vascular Organoids Using ROCK Inhibitors and Microwell Confinement

Published on: December 13, 2024

3.0K

相关实验视频

Last Updated: Jan 23, 2026

Efficient Vascularization of Kidney Organoids through Intracelomic Transplantation in Chicken Embryos
07:35

Efficient Vascularization of Kidney Organoids through Intracelomic Transplantation in Chicken Embryos

Published on: February 17, 2023

2.4K
Technique for Obtaining Mesenchymal Stem Cell from Adipose Tissue and Stromal Vascular Fraction Characterization in Long-Term Cryopreservation
05:57

Technique for Obtaining Mesenchymal Stem Cell from Adipose Tissue and Stromal Vascular Fraction Characterization in Long-Term Cryopreservation

Published on: December 30, 2021

3.9K
Author Spotlight: Improving Reproducibility in Vascular Organoids Using ROCK Inhibitors and Microwell Confinement
04:41

Author Spotlight: Improving Reproducibility in Vascular Organoids Using ROCK Inhibitors and Microwell Confinement

Published on: December 13, 2024

3.0K

科学领域:

  • 生物医学工程 生物医学工程
  • 干细胞生物学 干细胞生物学
  • 癌症研究 癌症研究

背景情况:

  • 血管系对于组织功能和疾病过程至关重要.
  • 现有的模型,如球状体,具有短暂的血管成分,而iPSC衍生的有机体则显示出可变的成熟度和可再生性.

研究的目的:

  • 开发一个持续形成的,自由浮动的,长期的血管化介质细胞器官 (VMO) 模型.
  • 评估VMOs的稳定性,复杂性和生理相关性,用于生物研究.

主要方法:

  • 在最小的Matrigel支架中共同培养人类静脉内皮细胞 (HUVECs) 和介质/干细胞 (MSCs).
  • 利用VMOs通过移植乳腺癌细胞来建模树叶与瘤相互作用和骨髓转移.

主要成果:

  • 维莫体在长达60天内表现出稳定的血管系统,显示组织成熟,炎症,ECM重塑和内皮发育.
  • 与传统的球形相比,VMOs表现出增强的血管复杂性,持续的ECM生产和更高的细胞活力.
  • 该模型保留了MSC异质性,包括周血管细胞,并成功模拟了用于转移研究的树突瘤.

结论:

  • 持续形成的VMOs为长期的血管生物学研究提供了一个强大的平台.
  • 这种模型使得能够研究树叶动力学,癌症进展和骨髓转移.
  • VMOs在药物测试和疾病建模中提供了潜在的应用.