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Updated: Jan 23, 2026

A Fluorogenic Peptide Cleavage Assay to Screen for Proteolytic Activity: Applications for coronavirus spike protein activation
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工程CRISPR-Cas13a系统具有增强的目标RNA裂变活性和减少的附带活性,用于治疗应用

Wenxia Zhang1, Haili Wang1, Dongzi Liu1

  • 1State Key Laboratory of Virology and Biosafety, College of Life Sciences, Wuhan University, Wuhan, Hubei 430072, China.

Molecular therapy. Nucleic acids
|January 22, 2026
PubMed
概括

这项研究通过优化Cas蛋白和crRNA来改进CRISPR-Cas13a系统. 改进后的系统显示了针对治疗应用的更大目标RNA裂变和减少的附带活性.

关键词:
这就是CRISPR-Cas13a.MT:寡核酸:治疗方法和应用.抗病毒应用程序 抗病毒应用程序切割活动的切割活动.担保活动担保活动.这就是 crRNARNA.

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