全免疫-炎症值作为脑转移患者的独立预后标志物
Jiacheng Li1,2,3, Menghan Liu4, Yingtong Liu1
1College of Medical and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
Frontiers in oncology
|January 22, 2026
概括
全免疫炎症值 (PIV) 是大脑转移 (BM) 患者整体存活期的重要独立预后因素. 将PIV纳入等级预后评估 (GPA) 号码表可以改善个性化生存预测的风险分层.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 生物标志物研究 生物标志物研究
背景情况:
- 系统性炎症和免疫失调对癌症的进展和生存至关重要.
- 全免疫炎症值 (PIV) 是一个复合生物标志物,反映了免疫炎症状态.
- 在大脑转移 (BM) 中PIV的预后价值尚不清楚.
研究的目的:
- 在脑转移 (BM) 患者中评估泛免疫炎症值 (PIV) 的预后意义.
- 评估PIV在与分级预后评估 (GPA) 结合时改善风险分层的实用性.
主要方法:
- 一项追溯的队列研究,对3856名放射性确认的BM患者进行了追溯的队列研究.
- 从全血细胞计数 (中性细胞 × 血小板 × 单细胞 / 淋巴细胞) 计算PIV.
- 多变量考克斯模型和PIV增强的GPA名谱被用于预后分析和验证.
主要成果:
- 在BM患者中,高PIV独立地与更糟糕的整体存活率 (OS) 相关 (HR 1.40).
- 在各种治疗方式,瘤类型和性别中,PIV仍然具有预后性.
- 将PIV添加到GPA中略有改善了风险歧视和名图的校准.
结论:
- 全免疫炎症值 (PIV) 是BM患者的OS的独立预后因素.
- 一个PIV+GPA nomogram为个性化生存预测提供了改进的风险分层.
- 对于例行临床实施,需要进一步的外部验证.
相关概念视频
Inflammation
61.8K
Overview
61.8K
Introduction to Test of Independence
2.9K
In statistics, the term independence means that one can directly obtain the probability of any event involving both variables by multiplying their individual probabilities. Tests of independence are chi-square tests involving the use of a contingency table of observed (data) values.
The test statistic for a test of independence is similar to that of a goodness-of-fit test:
The test statistic for a test of independence is similar to that of a goodness-of-fit test:
2.9K
Hypothesis Test for Test of Independence
7.4K
The test of independence is a chi-square-based test used to determine whether two variables or factors are independent or dependent. This hypothesis test is used to examine the independence of the variables. One can construct two qualitative survey questions or experiments based on the variables in a contingency table. The goal is to see if the two variables are unrelated (independent) or related (dependent). The null and alternative hypotheses for this test are:
H0: The two variables (factors)...
H0: The two variables (factors)...
7.4K
Law of Independent Assortment
62.4K
While Mendel’s Law of Segregation states that the two alleles for one gene are separated into different gametes, a different question of how different genes are inherited remains. For example, is the gene for tall plants inherited with the gene for green peas? Mendel asked this question by experimenting with a dihybrid cross; a cross in which both parents are homozygous for two distinct traits resulting in an F1 generation that are heterozygous for both traits.
62.4K
What is the Immune System?
127.1K
Overview
127.1K
Independent and Dependent Sources
2.5K
In electrical circuits, sources play a crucial role in providing power for the operation of the circuit. These sources can be broadly categorized into two types: independent and dependent.
Independent voltage or current sources supply a fixed amount of voltage or current, respectively, which is unaffected by other elements within the circuit. These are represented using specific symbols. Independent voltage sources are symbolized with polarities (+ and -), indicating the direction of the...
Independent voltage or current sources supply a fixed amount of voltage or current, respectively, which is unaffected by other elements within the circuit. These are represented using specific symbols. Independent voltage sources are symbolized with polarities (+ and -), indicating the direction of the...
2.5K


