在高级BOT-SCC的新辅助免疫疗法后转化TORS:一项回顾性研究
Quanquan Lin1,2, Yingjuan Zhang3, Jinlong Sun2
1Department of Stomatology, The First Medical Center of People's Liberation Army (PLA) General Hospital, Beijing, China.
Frontiers in oncology
|January 22, 2026
概括
使用 pembrolizumab 的新辅助疗法使得通过口腔机器人手术 (TORS) 实现了先进的舌底状细胞癌 (BOT-SCC) 的治疗. 这种方法以最小的并发症和良好的功能结果实现了彻底切除,这表明TORS在选择的BOT-SCC患者中是可行的.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 机器人手术 机器人手术
背景情况:
- 先进的舌底状细胞癌 (BOT-SCC) 传统上对横口切除提出挑战,原因是深入入侵和边缘困难.
- 透口机器人手术 (TORS) 提供了极小侵入性治疗的潜力,但在先进的BOT-SCC病例中受到限制.
研究的目的:
- 为了评估新辅助疗法的有效性,使TORS能够在晚期BOT-SCC患者中发挥作用.
- 评估经手术后的结果,功能恢复,以及在新辅助疗法和TORS.之后的瘤控制.
主要方法:
- 对9名晚期BOT-SCC患者 (阶段≥T4N2bM0) 的回顾性分析.
- 患者接受了三次新辅助 pembrolizumab 循环,其次是 TORS 和部剖析.
- 评估了放射反应,瘤缩,手术指标,并发症 (Clavien-Dindo) 和功能结果 (MDADI,FOIS,GRBAS).
主要成果:
- 新辅助疗法导致了显著的瘤衰退,有66.7%的部分反应和平均瘤减少35.6%.
- 所有患者都实现了R0切除,可接受的手术时间和最小的血液损失.
- 瘤缩小与手术时间和血液损失相反相关;在3个月后的功能结果是有利的,没有重大并发症.
结论:
- 新辅助疗法可以使先进的BOT-SCC候选人成为TORS的候选人,从而促进瘤学上健全的切除.
- 这种方法显示了低的术后发病率和有前途的早期功能恢复.
- 需要进一步的前性研究来完善患者选择,并探索以生物标志物为指导的减强策略.
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