针对性疗法和免疫疗法在血液性恶性瘤中的眼部毒性
Mohammad S Aqil1, Yzen Al-Marrawi1, Marcus Yaldo1
1Oakland University William Beaumont School of Medicine, Rochester, MI, United States.
Frontiers in oncology
|January 22, 2026
概括
针对血液癌症的现代癌症治疗方法可能会导致眼睛问题. 了解这些眼部毒性对于医生来说至关重要,以管理患者的护理和改善患者的生活质量.
科学领域:
- 眼科医生 眼科 眼科
- 血液学 血液学 血液学
- 在瘤学瘤学.
背景情况:
- 向疗法和免疫疗法彻底改变了血液癌症的治疗方法.
- 这些先进的治疗方法可能会导致显著的,往往被忽视的,眼部不良影响.
- 眼部毒性影响患者的生活质量和治疗决策.
研究的目的:
- 审查与现代向和免疫疗法相关的眼部毒性,用于血液恶性瘤.
- 综合各种研究类型和药监数据的证据.
- 突出眼部副作用的范围及其管理.
主要方法:
- 系统的文献审查,包括病例报告,临床试验和观察性研究.
- 分析来自药监数据库的数据.
- 在不同类型的血液癌症疗法中对眼部副作用的证据的综合分析.
主要成果:
- 眼部副作用在各种疗法类别中很常见:细胞疗法,激酶抑制剂,免疫检查点抑制剂,抗体药物联合剂和蛋白酶抑制剂.
- 具体的毒性包括神经眼科症状 (CAR T细胞),视网膜并发症 (激酶抑制剂),炎症性眼睛疾病 (免疫检查点抑制剂) 和眼睛表面疾病 (抗体-药物联合体).
- 虽然许多影响是可逆的,但有些可能导致视力威胁的并发症,需要眼科干预.
结论:
- 来自血液癌症治疗的眼睛毒性具有广泛的临床谱,取决于药物类别.
- 癌症专家和眼科医生之间提高意识和跨学科合作对于早期检测和管理至关重要.
- 需要进一步的研究,特别是关于儿科数据和长期眼部结果.
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