在治疗前列腺癌和良性前列腺增生症方面探索加工网状皮提取物的治疗潜力
Cheng-Yang Hsieh1,2, Khyle Suratos3,4, Ching-Chiung Wang5,6,7,8
1Department of Food Science, National Taiwan Ocean University, Keelung 202, Taiwan.
Current pharmaceutical design
|January 22, 2026
概括
花网状的提取物对前列腺癌细胞具有抗增殖作用. 来自该源的hesperidin和narirutin具有治疗前列腺癌 (PCa) 和良性前列腺增生 (BPH) 的治疗潜力.
科学领域:
- 药理学和生物信息学 药理学和生物信息学
- 自然产品化学 自然产品化学
- 在瘤学瘤学.
背景情况:
- 花网状植物 (Citrus reticulata,简称CR) 传统上用于医学.
- 它含有已知的抗氧化和抗癌特性的hesperidin和narirutin.
研究的目的:
- 研究CR水提取物对DU-145前列腺癌细胞的抗增殖活性.
- 使用网络药理学和分子对接,探索hesperidin和narirutin在前列腺癌 (PCa) 和良性前列腺增生 (BPH) 的治疗潜力.
主要方法:
- 细胞毒性测试以确定抗癌疗效 (IC50).
- 用于目标识别的生物信息学.
- 网络药理学用于途径分析 (GO,KEGG,DisGeNET).
- 分子对接用于化合物-标相互作用的验证.
主要成果:
- 在土壤中加工的CR提取物显示出强大的抗癌活性 (IC50 = 1.789 mg/mL).
- 发现的关键途径包括AGE-RAGE信号,p53信号,炎症,血管新生和亡.
- 赫斯佩里丁和纳里鲁丁对预测的目标表现出强烈的结合亲和力.
结论:
- CR提取物,hesperidin和narirutin显示出对PCa和BPH的显著治疗潜力.
- AGE-RAGE和p53信号通路与它们的作用机制有关.
- 这些发现支持CR衍生化合物的发展,作为未来的治疗方法.
关键词:
类网状植物 (Citrus reticulata) 是一种类网状植物.良性前列腺增生症 良性前列腺增生症这就是hesperidin.纳里鲁丁 (narirutin) 是一种常见的语言.网络药理学.前列腺癌是前列腺癌.更多相关视频
06:04Surgical Treatment for Benign Prostatic Hyperplasia: Holmium Laser Enucleation of the Prostate HoLEP.
Published on: March 6, 2018
17.6K
08:38Renal Capsule Xenografting and Subcutaneous Pellet Implantation for the Evaluation of Prostate Carcinogenesis and Benign Prostatic Hyperplasia
Published on: August 28, 2013
26.1K
相关概念视频
Treatment Resistant Cancers
3.7K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.7K
Potential Energy
42.4K
The energy stored by a structure and location of matter in space is called potential energy. For instance, raising a kettlebell changes its spatial location and increases its potential energy. Similarly, a stretched rubber band contains potential energy which, under certain conditions, can be converted into other forms of energy, such as kinetic energy.
Chemical bonds that form attractive forces between atoms also contain potential energy, called chemical energy. When a chemical reaction...
Chemical bonds that form attractive forces between atoms also contain potential energy, called chemical energy. When a chemical reaction...
42.4K
Therapeutic Index
6.7K
The therapeutic index of a drug is a key parameter in pharmacology that quantifies the relative safety of a drug by calculating the ratio between the dose that causes toxicity in half the population (50%) to the dose that proves to be effective for half the population (50%). It provides a spectrum of doses for a particular drug ranging from effective to potentially toxic. To illustrate, consider an anticoagulant agent like warfarin. It possesses a narrow window within its therapeutic index to...
6.7K
Standard Electrode Potentials
50.0K
On comparing the reactivity of silver and lead, it is observed that the two ionic species, Ag+ (aq) and Pb2+ (aq), show a difference in their redox reactivity towards copper: the silver ion undergoes spontaneous reduction, while the lead ion does not. This relative redox activity can be easily quantified in electrochemical cells by a property called cell potential. This property is commonly known as cell voltage in electrochemistry, and it is a measure of the energy which accompanies the charge...
50.0K
Therapeutic Communication
7.7K
Communication is a lifelong learning process. Through therapeutic communication, nurses can collect relevant assessment data, provide education and counseling, and interact during nursing interventions. Sending and receiving messages occur through verbal and nonverbal communication techniques and can happen separately or simultaneously.
Verbal communication depends on language or a prescribed way of using words so that people can share information effectively. The critical aspects of verbal...
Verbal communication depends on language or a prescribed way of using words so that people can share information effectively. The critical aspects of verbal...
7.7K
Cell Potential and Free Energy
46.3K
Thermodynamics of a Redox Reaction
Thermodynamics is the branch of physics dealing with the relationship between heat and other forms of energy. In an electrochemical cell, chemical energy is converted into electrical energy.
Thus, a link can be predicted between cell potential, free energy change, and the equilibrium constant for the reaction. Cell potential can also be measured as the oxidant or the reducing strength, and similar acid-base strength measures are reflected in equilibrium...
Thermodynamics is the branch of physics dealing with the relationship between heat and other forms of energy. In an electrochemical cell, chemical energy is converted into electrical energy.
Thus, a link can be predicted between cell potential, free energy change, and the equilibrium constant for the reaction. Cell potential can also be measured as the oxidant or the reducing strength, and similar acid-base strength measures are reflected in equilibrium...
46.3K
