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Updated: Jan 23, 2026

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在过敏气道炎症中恢复免疫平衡:河平川颗粒通过PD-1/PD-L1通道调节Th17/Treg

Lei Yang¹, Xuebing Li¹, Zongfa Sun¹

¹Department of Intensive Care Medicine, Second Affiliated Hospital of Anhui University of Traditional Chinese Medicine, Hefei, Anhui 230061, China.

Combinatorial chemistry & high throughput screening

|January 22, 2026

概括

河平川颗粒 (YP) 通过减少Th17细胞和增加Treg细胞,在过敏呼吸道炎症中恢复免疫平衡. 这涉及调节PD-1/PD-L1通路,减少炎症和转移细胞因子配置.

科学领域:

免疫学免疫学免疫学
药理学药理学是指药理学的学科.

背景情况:

过敏性气道炎症 (AAI) 与Th17/Treg失衡和PD-1/PD-L1通路问题有关.
河平川颗粒 (YP) 用于喘治疗的免疫调节机制尚未完全理解.

研究的目的:

在大鼠模型中研究YP对AAI的免疫调节作用.
阐明PD-1/PD-L1通路在YP治疗作用中的作用.

主要方法:

用AAI的老鼠模型来评估YP效应.
流细胞计分析了Th17/Treg细胞的比例.
测量了关键细胞因子 (IL-10,IL-17,TGF-β1) 和转录因子 (Foxp3,RORγt) 的基因和蛋白质表达.
进行了PD-L1淘汰和过度表达的研究.

主要成果:

YP治疗纠正了Th17/Treg不平衡,降低了Th17并增加了Treg细胞.
YP上调的抗炎细胞因子 (IL-10,TGF-β1) 和下调的促炎IL-17.
YP抑制了PD-1/PD-L1通路,与减少炎症相关.
PD-L1调节证实了其在YP对免疫细胞和细胞因子的影响中的作用.

结论:

YP通过调节Th17/Treg平衡来减轻AAI,可能是通过PD-1/PD-L1通路的抑制.
YP将细胞因子环境转移到抗炎状态,为喘提供潜在的治疗机制.

关键词:

在PD-1/PD-L1信号通路中.Th17/Treg 的不平衡.阳河平川颗粒阳河平川颗粒过敏的气道炎症过敏的气道炎症喘喘是一种这是一种炎症,炎症.

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