循环中性粒细胞和单细胞计数与心率可变性指数相反相关:马斯特里赫特研究
Haifa Maalmi1,2, Kristiaan Wouters3,4, Nicolaas C Schaper3
1German Diabetes Center (DDZ), Institute for Clinical Diabetology, Leibniz Center for Diabetes Research at Heinrich Heine Universität Düsseldorf Germany.
较高的中性粒细胞和单细胞数量与心率变化 (HRV) 的减少有关,这是心脏自主功能障碍的指标. 这些发现表明,天生的免疫细胞在心脏健康中起着作用,无论性别或葡萄糖状况如何.
科学领域:
- 心脏病学 心脏病学
- 免疫学 免疫学 免疫学
- 公共卫生 公共卫生
背景情况:
- 心率变化 (HRV) 表明心脏自主神经系统的功能.
- 免疫细胞,特别是白细胞,与降低HRV有关.
- 白细胞的特定作用及其与性别和葡萄糖代谢之间的关联仍然不清楚.
研究的目的:
- 调查白细胞计数和HRV指数之间的横截面关联.
- 检查性别或葡萄糖代谢状态是否会改变白细胞和HRV之间的关系.
主要方法:
- 利用了1888名马斯特里赫特研究参与者的数据.
- 测量白细胞子集 (中性粒细胞,单细胞,淋巴细胞等) 通过自动化血液学和流细胞计.
- 使用24小时心电图评估HRV,计算时间域和频域得分.
主要成果:
- 增加的中性粒细胞和单细胞计数与较低的时间域和频域HRV得分显著相关.
- 这些关联在调整多个共变量后仍然显著.
- 对于性别或葡萄糖代谢状态,没有观察到显著的效果改变.
结论:
- 中性粒细胞和单细胞水平升高与一般人群中HRV降低相关.
- 这些发现凸显了先天性免疫过程和炎症在心脏自主功能障碍中的潜在参与.
- 观察到的关联是独立于性别和葡萄糖代谢状态.
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