Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Sperm Transport01:15

Sperm Transport

3.3K
The journey of sperm from its origin to the point of ejaculation begins within the seminiferous tubules of the testis. Here, Sertoli cells produce fluid that propels non-motile sperm through a series of conduits, starting with the straight tubules leading to the rete testis. This interconnected network of tubules acts as the initial pathway for sperm, guiding them into the efferent ductules and then into the epididymis for maturation.
The maturation phase occurs in the epididymis, where sperm...
3.3K
Sperm Structure and Semen Composition01:22

Sperm Structure and Semen Composition

10.7K
During ejaculation, males release around 2-5 milliliters of semen, which is a complex mixture of mature sperm and various fluids produced by accessory glands. The mature sperm cells measure approximately 60 micrometers in length and consist of a head, neck, midpiece, and tail. The head is flattened and tapered, measuring about 4 to 5 micrometers in length. It contains a nucleus with condensed chromosomes and an acrosome, a cap-like structure filled with enzymes essential for penetrating the...
10.7K
Ion Channels01:19

Ion Channels

91.2K
The movement of ions like sodium, potassium, and calcium into and out of the cell is essential to maintain the electrochemical gradient in living cells. The ion channels—a class of membrane transport proteins—help maintain this ionic gradient for the smooth functioning of physiological activities such as maintaining cell size and volume, conducting nerve impulses, and gas and nutrient exchange.
Ion channels are specialized integral membrane proteins on the plasma membrane that allow...
91.2K
Channel Rhodopsins01:11

Channel Rhodopsins

3.1K
Most organisms use photoreceptors to sense and respond to light. Examples of photoreceptors include bacteriorhodopsins and bacteriophytochromes in some bacteria, phytochromes in plants, and rhodopsins in the photoreceptor cells of the vertebral retina. The light-sensitive property of these receptors is because of the bound chromophores, such as bilin in the phytochromes and retinal in the rhodopsins.
Rhodopsins belong to the family of cell surface proteins called G-protein coupled receptors,...
3.1K
Non-gated Ion Channels01:24

Non-gated Ion Channels

8.0K
Ion channels are specialized proteins on the plasma membrane that allow charged ions to pass down their electrochemical gradient. Their main function is to maintain the membrane potential which is critical for cell viability. These channels are either gated or non-gated and can transport more than a thousand ions within milliseconds for the cellular event to occur.
Compared to the gated ion channels, the non-gated channels, also known as leakage or passive channels, have no gating mechanism....
8.0K
Channels of Non-Verbal Communication01:28

Channels of Non-Verbal Communication

378
Non-verbal communication plays a critical role in human interaction, influencing how individuals perceive emotions and psychological states. It operates through four primary channels: facial expressions, eye contact, body language, and touch. These non-verbal cues help convey meaning beyond spoken language and are often culturally influenced.Facial Expressions and Emotional RecognitionFacial expressions are among the most powerful and universal forms of non-verbal communication. Research has...
378

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

A Scalable Flow Cytometry Assay to Evaluate CatSper-mediated Ca<sup>2+</sup> Influx Triggered by High-K<sup>+</sup>/High-pH Stimulation in Mouse Sperm.

Andrology·2026
Same author

Identification of keystone taxa shaping biocrust formation and biodeterioration of limestone monuments in the Xiaoling Tomb of the Ming Dynasty.

Environmental microbiome·2026
Same author

A multicenter, prospective sibling oocyte study revealed that HyperSperm<sup>™</sup> improves the number and quality of embryos in patients undergoing in vitro fertilization.

Journal of translational medicine·2026
Same author

Carbon-fixing bacteria and sediment organic carbon response to the introduction of mangrove plant Sonneratia caseolaris.

BMC biology·2026
Same author

Dual regulation of NFS1 by TRIM67-mediated degradation and CEBPA-driven transcription modulates colorectal cancer progression.

Cellular signalling·2026
Same author

Sex-specific gray matter underpinnings of anxiety and their mediating mechanisms in <i>de novo</i> Parkinson's disease.

Frontiers in aging neuroscience·2026

相关实验视频

Updated: Jan 23, 2026

Fluorimetric Techniques for the Assessment of Sperm Membranes
08:58

Fluorimetric Techniques for the Assessment of Sperm Membranes

Published on: November 28, 2018

14.1K

SPINK3-精子相互作用确定了一个稳定的精子子亚群,具有完整的CatSper通道.

Anabella R Nicolli1, Xiaofang Huang2, Lucia Zalazar1

  • 1Facultad de Ciencias Exactas y Naturales, Instituto de Investigaciones Biológicas (IIB-FCEyN/CONICET), Universidad Nacional de Mar del Plata, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Mar del Plata, Buenos Aires, Argentina.

Journal of cellular physiology
|January 22, 2026
PubMed
概括
此摘要是机器生成的。

精子蛋白酶抑制剂SPINK3通过阻断CATSPER1处理来防止过早的精子电容. 这种作用保护了精子功能,突出了SPINK3的作用.

关键词:
在CATSPER1中这就是SPINK3的原因.丧失能力的因素是什么膜稳定稳定 膜稳定蛋白酶抑制是一种抑制.精子容量化能力 精子容量化能力

更多相关视频

Fish Sperm Assessment Using Software and Cooling Devices
07:57

Fish Sperm Assessment Using Software and Cooling Devices

Published on: July 28, 2018

9.2K
Sperm Collection and Computer-Assisted Sperm Analysis in the Teleost Model Japanese Medaka Oryzias latipes
06:49

Sperm Collection and Computer-Assisted Sperm Analysis in the Teleost Model Japanese Medaka Oryzias latipes

Published on: October 6, 2022

4.7K

相关实验视频

Last Updated: Jan 23, 2026

Fluorimetric Techniques for the Assessment of Sperm Membranes
08:58

Fluorimetric Techniques for the Assessment of Sperm Membranes

Published on: November 28, 2018

14.1K
Fish Sperm Assessment Using Software and Cooling Devices
07:57

Fish Sperm Assessment Using Software and Cooling Devices

Published on: July 28, 2018

9.2K
Sperm Collection and Computer-Assisted Sperm Analysis in the Teleost Model Japanese Medaka Oryzias latipes
06:49

Sperm Collection and Computer-Assisted Sperm Analysis in the Teleost Model Japanese Medaka Oryzias latipes

Published on: October 6, 2022

4.7K

科学领域:

  • 生殖生物学 生殖生物学
  • 分子内分泌学分子内分泌学
  • 精子生理学 精子生理学

背景情况:

  • 精子电容需要膜蛋白的蛋白质分解重塑,包括CatSper通道.
  • CatSper通道对于精子过度激活和男性生育能力至关重要.
  • SPINK3是一种已知的减容因子,可以抑制过早的电容.

研究的目的:

  • 在精子电容化过程中识别CATSPER1处理的生理抑制剂.
  • 阐明SPINK3在调节CatSper通道功能和精子电容中的作用.

主要方法:

  • 研究了SPINK3对小鼠精子中CATSPER1裂变的抑制作用.
  • 分析了SPINK3.3的局部化和膜效应.
  • 评估了SPINK3对精子电容性标记物的影响,如pTyr发育和胆固醇排泄.

主要成果:

  • SPINK3被确定为CATSPER1处理的第一个生理抑制剂.
  • SPINK3阻断了电容诱导的CATSPER1裂变,保持了具有完整CatSper通道的精子子群.
  • SPINK3稳定了精子膜组织,并延迟了胆固醇流出,局部化到主要的片子膜.

结论:

  • SPINK3 是精子电容性的多功能调节器.
  • 在女性生殖道中,SPINK3在塑造精子子群中起着至关重要的作用.
  • SPINK3对CATSPER1处理的抑制是保持精子功能和生育能力的关键.