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聚乙烯纳米颗粒在雄性斑马鱼中引起性别特异性毒性,这种毒性可以通过氨酸减轻
Wanjing Liu1,2, Chunhua Zhan2, Min Zeng1
1College of Marine Sciences, South China Agricultural University, Guangzhou, China.
Environmental toxicology
|January 22, 2026
概括
微塑料 (MPs) 通过破坏激素通路并导致细胞损伤,损害斑马鱼的繁殖. 黑色素治疗保护了这些毒性影响,显示了减轻MP生殖损害的希望.
科学领域:
- 环境毒理学环境毒理学
- 生殖生物学 生殖生物学
- 纳米技术 纳米技术
背景情况:
- 微塑料 (MP) 是普遍存在的环境污染物.
- 人们越来越担心它们的生殖毒性.
- 对于MP生殖毒性的分子机制尚未完全理解.
研究的目的:
- 在成年斑马鱼中研究聚乙烯纳米颗粒 (PSNPs) 的生殖毒性.
- 探索潜在的分子机制,包括氧化应激和HPG轴中断.
- 评估黑激素对PSNP诱导的生殖毒性的保护作用.
主要方法:
- 成年斑马鱼被暴露在PSNP (0,0.1,1 mg/L) 中14天.
- 与黑激素 (1μM) 进行并发治疗.
- 测量了淋巴体和大脑体指数.
- 评估了组织病理学,下丘脑-垂体-淋巴腺 (HPG) 轴的基因转录,性激素水平,氧化应激和亡.
主要成果:
- 暴露于1毫克/升PSNP降低了淋巴体和脑体索引,导致淋巴体组织损伤.
- PSNP 破坏了HPG轴基因表达,改变了性激素水平.
- PSNP诱导了淋巴体和脑组织中的氧化应激和亡,具有取决于性别的效应.
- 黑色素联合治疗大大改善了PSNP诱导的毒性.
结论:
- 聚乙烯纳米颗粒在斑马鱼中表现出生殖毒性,影响HPG轴功能,并导致氧化应激和亡.
- 毒性影响是性别特异的.
- 黑色素显示出减轻微塑料诱导的生殖毒性的潜力.
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