在国外住院的儿童中,多药耐药细菌的殖民化-芬兰的一项研究
Hilda A F Mäkinen1,2,3, Mikael J Kajova1,2,3,4, Tamim S B Khawaja1,2,3,4
1FIMAR, Finnish Multidisciplinary Centre of Excellence in Antimicrobial Resistance Research, University of Helsinki, Helsinki, Finland.
Journal of travel medicine
|January 22, 2026
概括
在国外住院的儿童经常获得多抗药生物体 (MDROs),低收入国家殖民率增加. 建议从低低收入国家返回的儿童旅行者进行查,特别是那些最近使用了抗生素的人.
科学领域:
- 全球健康 全球健康
- 传染性疾病 传染性疾病
- 微生物学 微生物学
背景情况:
- 国际旅行是全球传播抗菌素耐药性 (AMR) 的重要驱动因素.
- 在国外住院的儿童,特别是在低收入和中等收入国家 (LMICs),面临着多药耐药生物体 (MDRO) 殖民的风险.
- 关于儿童群体在旅行中获得的MDROs的研究有限.
研究的目的:
- 评估在国外住院后儿童中MDRO殖民的流行情况.
- 在儿科患者中识别与旅行获得的MDRO殖民化相关的风险因素.
主要方法:
- 在HUS赫尔辛基大学医院 (2010-2024) 的儿科患者的MDRO查数据的分析.
- 纳入标准:在过去12个月内在国外住院的儿科患者.
- 多变量分析以确定MDRO殖民化的独立风险因素.
主要成果:
- 在459名被查的儿科患者中,有158名 (34.4%) 被MDROs殖民.
- 常见的MDRO包括ESBL-PE (29.0%) 和MRSA (7.6%);CPE在3.1%中被发现.
- 殖民化的独立风险因素是抗生素使用,旅行类型和国家收入水平,在LMICs中比率更高.
结论:
- 在国外住院的儿童中,MDRO殖民性普遍存在,与国家收入水平有很强的反向相关性.
- 查和感染控制对于从国外接受护理返回的儿科患者至关重要,特别是来自LMIC的儿科患者.
- 针对性干预应考虑VFR旅行,国外居住和最近使用抗生素作为额外的风险因素.
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