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相关概念视频

Drug Delivery: Overview01:16

Drug Delivery: Overview

753
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
753
Drug Delivery: Enteral Route01:18

Drug Delivery: Enteral Route

1.6K
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
1.6K
Drug Delivery: Parenteral Route01:29

Drug Delivery: Parenteral Route

1.6K
The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
1.6K
Targets for Drug Action: Overview01:26

Targets for Drug Action: Overview

10.1K
Drugs target macromolecules to modify ongoing cellular processes. Primary drug targets include receptors, ion channels, transporters, and enzymes.
Receptors are either membrane-spanning or intracellular proteins, which upon binding a ligand, get activated and transmit the signal downstream to elicit a response. Drugs bind receptors, either mimicking the action of endogenous ligands or blocking the receptor activity to bring about a modified response. Nearly 35% of approved drugs target the G...
10.1K
Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

751
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
751
Colors and Magnetism03:02

Colors and Magnetism

14.0K
Color in Coordination Complexes
When atoms or molecules absorb light at the proper frequency, their electrons are excited to higher-energy orbitals. For many main group atoms and molecules, the absorbed photons are in the ultraviolet range of the electromagnetic spectrum, which cannot be detected by the human eye. For coordination compounds, the energy difference between the d orbitals often allows photons in the visible range to be absorbed and emitted, which is seen as colors by the human...
14.0K

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相关实验视频

Updated: Jan 23, 2026

Comprehensive Evaluation of the Effectiveness and Safety of Placenta-Targeted Drug Delivery Using Three Complementary Methods
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磁导微机器人用于有针对性的药物输送.

Yi Zhang1, Jiaqi Li2, Lijie Yin3

  • 1School of Biomedical Engineering, Institute of Medical Robotics, Shanghai Key Laboratory of Flexible Medical Robotics, National Engineering Research Center of Advanced Magnetic Resonance Technologies For Diagnosis and Therapy (NERC-AMRT), Shanghai Jiao Tong University, Shanghai, China.

Advanced healthcare materials
|January 22, 2026
PubMed
概括
此摘要是机器生成的。

磁导微机器人提供精确,最少的侵入性药物输送,克服传统方法的局限性. 生物相容性和导航方面的挑战仍然存在,但未来的进步有望在向治疗方面取得重大进展.

关键词:
临床翻译 临床翻译药物输送是药物输送的过程.微型机器人 微型机器人实时跟踪跟踪实时跟踪刺激-响应药物释放.

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Contrast Ultrasound Targeted Treatment of Gliomas in Mice via Drug-Bearing Nanoparticle Delivery and Microvascular Ablation
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Echocardiography-guided Injection for Targeted and Reliable Intramyocardial Stem Cell Delivery in a Rat Model of Myocardial Infarction
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相关实验视频

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Echocardiography-guided Injection for Targeted and Reliable Intramyocardial Stem Cell Delivery in a Rat Model of Myocardial Infarction
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科学领域:

  • 生物医学工程 生物医学工程
  • 纳米技术纳米技术
  • 药物输送系统 药物输送系统

背景情况:

  • 传统的药物输送方法面临着诸如针对性差异和系统性副作用等挑战.
  • 磁导微机器人可以在生物系统中提供更高的精度和最少的侵入性导航.

研究的目的:

  • 审查磁导微机器人的最新进展,以针对药物输送.
  • 突出微机器人技术临床转化方面的挑战和未来方向.

主要方法:

  • 对各种微机器人设计 (例如螺旋式游泳器,生物混合系统) 的微制造技术的审查.
  • 集成磁性启动,生物材料和对刺激有反应的药物释放机制.
  • 在实时体内成像和跟踪技术 (超声波,MRI等) 的进步. ) 的情况.

主要成果:

  • 开发能够运输药物,细胞或精神药剂的微机器人.
  • 通过各种刺激引发的受控货物释放的演示.
  • 通过先进的成像技术实现了成功的体内指导和监测.

结论:

  • 磁导微机器人显示了针对性治疗和再生医学的巨大潜力.
  • 克服生物相容性,运动,释放精度和监管批准方面的挑战对于临床翻译至关重要.
  • 持续的跨学科研究是实现微机器人在精准医学中的全部潜力的关键.