在老年人人口队列中,静坐行为与认知之间的关联
Marissa A Gogniat1, Yueting Wang2, Chung-Chou H Chang2,3
1Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Journal of Alzheimer's disease : JAD
|January 22, 2026
概括
参与更久坐的老年人表现出较差的执行功能和记忆力. 减少久坐时间可能是预防阿尔茨海默病的关键策略.
科学领域:
- 老年学是指老年学的学科.
- 认知神经科学 认知神经科学
- 公共卫生 公共卫生
背景情况:
- 久坐不动的行为在老年人中很普遍,与不良健康结果有关.
- 久坐不动行为和认知功能之间的关系,特别是与阿尔茨海默病 (AD) 风险有关的关系,需要进一步调查.
研究的目的:
- 调查社区居住的老年人的久坐行为和认知表现之间的关联.
- 探索与认知衰退相关的久坐行为和APOE4基因型之间的潜在相互作用.
主要方法:
- 利用手腕加速计测量了来自Monongahela-Youghiogheny健康衰老团队 (MYHAT) 队列的193名参与者的静坐时间.
- 采用横截面线性回归模型,调整年龄,性别,教育,APOE4载体状态,以及中度至剧烈体力活动 (MVPA).
主要成果:
- 增加的久坐行为与较差的执行功能 (β = -0.06,p = 0.01) 和记忆性能 (β = -0.06,p = 0.05) 有显著的关联.
- 这些关联在调整为MVPA后被减弱.
- 在久坐时间和APOE4状态之间没有发现显著的相互作用,尽管趋势表明非载体中更强烈的关联.
结论:
- 较高的久坐行为水平与与阿尔茨海默病相关的认知领域的表现下降相关.
- 减少老年人的久坐时间可能成为预防AD的关键公共卫生和精准医学方法.
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