在非增殖性糖尿病视网膜病症中,毛细管不 perfusion 的一年进展使用非侵入性成像:CHART研究
Inês Pereira Marques1,2,3, Débora Reste-Ferreira1,4, Torcato Santos1,2,5
1AIBILI-Association for Innovation and Biomedical Research on Light and Image, Coimbra, Portugal.
Translational vision science & technology
|January 22, 2026
概括
视网膜毛细管非 perfusion 在一年内进展为轻度至中度的非增殖性糖尿病视网膜病变 (NPDR). 更严重的NPDR阶段显示稳定的非 perfusion 和增加的微动脉瘤周转率,表明潜在的超 perfusion.
科学领域:
- 眼科医生 眼科 眼科
- 糖尿病视网膜病变研究研究
- 医疗成像医学成像
背景情况:
- 糖尿病视网膜病变 (DR) 是导致视力丧失的主要原因.
- 非增殖性糖尿病视网膜病变 (NPDR) 是一个早期阶段,以视网膜变化为特征.
- 了解NPDR的进展对于及时干预至关重要.
研究的目的:
- 为了评估视网膜毛细管不 perfusion 的1年进展在轻度至重度的NPDR.
- 使用非侵入性视网膜成像技术进行评估.
- 为未来的临床试验提供定量数据.
主要方法:
- 该CHART研究招募了155名患有2型糖尿病和NPDR的参与者.
- 眼科检查,包括OCT和OCT血管学 (OCTA),在基线和12个月后进行.
- 混合效应模型分析了基于ETDRS严重程度尺度的疾病进展.
主要成果:
- 有轻度至中度NPDR (ETDRS水平35和43) 的眼睛在1年内显著增加了毛细血管不 perfusion.
- 严重的NPDR (47和53级) 显示出稳定的毛细血管不 perfusion.
- 在更严重的NPDR阶段观察到微动脉瘤周转率 (MAT) 的增加.
结论:
- 在轻度至中度的NPDR中,视网膜毛细血管不 perfusion显著进展.
- 在严重的NPDR中,非 perfusion 稳定,有证据表明过 perfusion 反应.
- 非侵入性成像为NPDR进展提供了有价值的数据.
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