相关实验视频
Updated: Jan 23, 2026

05:50
Ameliorating Osteoarthritis in Mice Using Silver Nanoparticles
Published on: June 2, 2023
1.8K
代诺苏马布功能化的纳米颗粒向巨细胞,以减轻与年龄相关的关节炎和骨质疏松症
Binghui Liao1, Rencong Wang2, Ming Ding1
1Department of Orthopedic Surgery, Xijing Hospital, The Fourth Military Medical University, Xi'an, China. sky_0821@163.com.
Journal of materials chemistry. B
|January 22, 2026
概括
代诺苏马布纳米颗粒 (DS@Lip-FA) 向巨细胞治疗与年龄相关的关节炎和骨质疏松症. 这种疗法改变了巨细胞平衡,减少炎症,促进老年患者的软骨和骨健康.
科学领域:
- 老年学是指老年学的学科.
- 免疫学 免疫学 免疫学
- 整形外科 整形外科 整形外科
- 纳米医学是一种纳米医学.
背景情况:
- 骨关节炎 (OA) 和骨质疏松症 (OP) 是老年人常见的退行性疾病.
- 这些条件往往并存,并共享RANKL/RANK信号通路.
- 德诺苏玛布 (DS) 显示出治疗OA和OP的潜力.
研究的目的:
- 研究DS如何通过调节巨细胞两极分化来缓解与年龄相关的OA-OP.
- 为了开发向性巨纳米颗粒 (DS@Lip-FA),由于DS的向性很差.
- 评估DS@Lip-FA对巨分化和随后的软骨/骨健康的影响.
主要方法:
- 用叶酸修饰的脂质体 (Lip-FA) 准备,装载DS (DS@Lip-FA).
- 利用了老化的人性化小鼠模型.
- 分析了巨细胞的两极分化 (M1/M2) 以及它对软质细胞和骨髓中酶干细胞 (BMSC) 的影响.
主要成果:
- 衰老增加了促炎性M1巨细胞和减少了抗炎性M2巨细胞,与RANKL升高相关.
- DS@Lip-FA治疗成功降低了M1和增加了M2巨细胞.
- 这种巨细胞极化转移减少了状细胞亡,促进了BMSC增殖/骨质生成,并降低了衰老.
结论:
- DS@Lip-FA通过调节巨细胞极化,有效治疗与年龄相关的OA-OP.
- 该疗法通过巨细胞调节影响状细胞和BMSC健康.
- DS@Lip-FA代表了一个有前途的治疗策略,用于老年患者与同时存在的OA和OP.
相关概念视频
Aging
636
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
636
The Effect of Aging on Tissues
3.4K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
3.4K
Changes in the Appendicular Skeleton with Age
3.4K
The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
3.4K
Pharmacodynamics in Geriatric Patients: Effects of Age
192
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
192
Functional Groups
87.9K
Functional groups are a group of atoms with characteristic properties, which when linked to the carbon skeleton of a molecule, alter the properties of that molecule. For example, the presence of certain functional groups on a molecule will make them hydrophilic, whereas others will make them hydrophobic. These functional groups are an indispensable part of organic chemistry and important components of biological molecules, such as carbohydrates, proteins, lipids, and nucleic acids. Each...
87.9K
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption
231
As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
231

