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Updated: Jan 23, 2026

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通过PI3/AKT/mTOR途径在口腔状细胞癌中PDGF-BB的作用:基于PCR的综合计算和实时PCR方法
Georgia Benitha J1,2, Pratibha Ramani3, Selvaraj Jayaraman4
1Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Chennai, India.
Asian Pacific journal of cancer prevention : APJCP
|January 22, 2026
概括
血小板衍生生长因子-BB (PDGF-BB) 在口腔状细胞癌 (OSCC) 中升高,激活PI3K/AKT/mTOR通路. 这表明PDGF-BB是OSCC的潜在生物标志物和治疗标.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 生物化学 生物化学
背景情况:
- 口腔状细胞癌 (OSCC) 是一种常见的恶性瘤,具有复杂的分子基础.
- 特定生长因子和信号通路在OSCC病变发生中的作用需要进一步阐明.
- 血小板衍生生长因子-BB (PDGF-BB) 已与各种癌症有关,但其在OSCC中的特定作用尚未完全理解.
研究的目的:
- 在OSCC中调查PDGF-BB的表达水平.
- 分析PDGF-BB对OSCC中的PI3K/AKT/mTOR信号通路的影响.
- 确定潜在的OSCC诊断生物标志物和治疗点.
主要方法:
- 在分析中使用UniProt和STRING用于PDGF-BB相互作用和PANTHER用于途径丰富.
- 通过ELISA对30名OSCC患者和30名对照患者的血清PDGF-BB水平进行定量分析.
- 使用RT-qPCR测量OSCC和相邻非瘤组织中的PI3K,AKT和mTORmRNA表达.
主要成果:
- 路径分析发现PI3K/AKT/mTOR路径与PDGF-BB.BB有显著的关联.
- 血清PDGF-BB水平在OSCC患者 (3.44 ng/mL) 中明显高于对照组 (1.38 ng/mL).
- 与非瘤组织相比,OSCC组织中PI3K,AKT和mTOR的mRNA表达明显上调.
结论:
- 在OSCC中,PDGF-BB显著上调,与PI3K/AKT/mTOR通路激活相关.
- 升高的PDGF-BB表明其对OSCC进展的贡献.
- PDGF-BB代表了OSCC的一个有前途的生物标志物和治疗标,具有针对性治疗的潜力.
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