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相关概念视频

Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...

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相关实验视频

Updated: Jun 5, 2026

Discovery of Driver Genes in Colorectal HT29-derived Cancer Stem-Like Tumorspheres
06:52

Discovery of Driver Genes in Colorectal HT29-derived Cancer Stem-Like Tumorspheres

Published on: July 22, 2020

解读Candida对口腔状细胞癌的基因组影响:一种生物信息学方法

Jothiha Shree1, Suganya Panneer Selvam1, Nitya Krishnasamy1

  • 1Department of Oral Pathology & Oral Biology, Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha University, India, Tamil Nadu, Chennai, India.

Asian Pacific journal of cancer prevention : APJCP
|January 22, 2026
PubMed
概括

坎迪达菌感染通过免疫信号通路驱动口腔癌 (OSCC) 的进展. 染色体2,9和16上的关键基因组区域可能为这种复杂的相互作用提供治疗点.

关键词:
生物信息学是一种生物信息学.一个字符串数据库.癌症研究 癌症研究这是Candida的候选.染色体映射是染色体的映射.

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In Vivo CRISPR/Cas9 Screening to Simultaneously Evaluate Gene Function in Mouse Skin and Oral Cavity
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Development of Compendium for Esophageal Squamous Cell Carcinoma
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Published on: April 12, 2024

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Last Updated: Jun 5, 2026

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06:52

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Published on: July 22, 2020

In Vivo CRISPR/Cas9 Screening to Simultaneously Evaluate Gene Function in Mouse Skin and Oral Cavity
07:52

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Published on: November 2, 2020

Development of Compendium for Esophageal Squamous Cell Carcinoma
03:36

Development of Compendium for Esophageal Squamous Cell Carcinoma

Published on: April 12, 2024

科学领域:

  • 口腔状细胞癌 (OSCC) 的研究.
  • 菌类学和免疫学 菌类学和免疫学
  • 生物信息学和计算生物学

背景情况:

  • 坎迪达菌感染与口腔状细胞癌 (OSCC) 的进展有关.
  • 了解分子机制对于OSCC开发见解和治疗目标至关重要.
  • 生物信息学分析探索了与Candida相关的OSCC进展中的基因.

研究的目的:

  • 调查基因网络和生物途径在OSCC进展由于坎迪达菌感染.
  • 确定参与坎迪达媒介OSCC发展的染色体位置.
  • 使用生物信息学方法进行全面分析.

主要方法:

  • 使用STRING数据库进行蛋白质与蛋白质相互作用 (PPI) 网络分析.
  • 免疫和炎症生物通路的丰富分析.
  • 基因本体学 (GO) 术语检查和丰富基因的染色体映射.

主要成果:

  • 细胞因子-细胞因子受体相互作用途径在免疫调节中显示出显著的丰富 (~80倍).
  • 其他丰富的途径包括病毒蛋白相互作用,DNA传感和Th17细胞分化.
  • 确定了免疫失调 (巨细胞增殖,IL-33,干扰素) 和染色体2,9,12和16上的关键基因组区域.

结论:

  • 免疫信号传递,特别是细胞因子相互作用,对于Candida介导的OSCC进展至关重要.
  • 2,9,16号染色体上的染色体位置可能含有治疗向的关键基因.
  • 这些发现有助于更好地理解在菌感染中免疫驱动的OSCC机制.