解读Candida对口腔状细胞癌的基因组影响:一种生物信息学方法
Jothiha Shree1, Suganya Panneer Selvam1, Nitya Krishnasamy1
1Department of Oral Pathology & Oral Biology, Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha University, India, Tamil Nadu, Chennai, India.
Asian Pacific journal of cancer prevention : APJCP
|January 22, 2026
概括
坎迪达菌感染通过免疫信号通路驱动口腔癌 (OSCC) 的进展. 染色体2,9和16上的关键基因组区域可能为这种复杂的相互作用提供治疗点.
科学领域:
- 口腔状细胞癌 (OSCC) 的研究.
- 菌类学和免疫学 菌类学和免疫学
- 生物信息学和计算生物学
背景情况:
- 坎迪达菌感染与口腔状细胞癌 (OSCC) 的进展有关.
- 了解分子机制对于OSCC开发见解和治疗目标至关重要.
- 生物信息学分析探索了与Candida相关的OSCC进展中的基因.
研究的目的:
- 调查基因网络和生物途径在OSCC进展由于坎迪达菌感染.
- 确定参与坎迪达媒介OSCC发展的染色体位置.
- 使用生物信息学方法进行全面分析.
主要方法:
- 使用STRING数据库进行蛋白质与蛋白质相互作用 (PPI) 网络分析.
- 免疫和炎症生物通路的丰富分析.
- 基因本体学 (GO) 术语检查和丰富基因的染色体映射.
主要成果:
- 细胞因子-细胞因子受体相互作用途径在免疫调节中显示出显著的丰富 (~80倍).
- 其他丰富的途径包括病毒蛋白相互作用,DNA传感和Th17细胞分化.
- 确定了免疫失调 (巨细胞增殖,IL-33,干扰素) 和染色体2,9,12和16上的关键基因组区域.
结论:
- 免疫信号传递,特别是细胞因子相互作用,对于Candida介导的OSCC进展至关重要.
- 2,9,16号染色体上的染色体位置可能含有治疗向的关键基因.
- 这些发现有助于更好地理解在菌感染中免疫驱动的OSCC机制.
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