作为前列腺癌和BPH治疗点的NF-κB (p65,p50),IL-18和IL-10:分子洞察炎症驱动的发病因子
Shailendra Dwivedi1, Sapna Saini1, Ajay -2
1Department of Biochemistry, All India Institute of Medical Sciences (AIIMS) Gorakhpur, Uttar Pradesh, 273008, India.
Asian Pacific journal of cancer prevention : APJCP
|January 22, 2026
概括
炎症标志物,核因子卡帕B (NF-κB) 和细胞因子IL-18/IL-10,在前列腺癌中升高. 这些生物标志物可能有助于诊断和分期前列腺癌,特别是在那些有职业暴露的人群中.
科学领域:
- 瘤学和免疫学
- 分子生物学分子生物学
背景情况:
- 前列腺癌是男性的主要恶性瘤,其发展与慢性炎症和环境因素有关.
- 核因子kappa B (NF-κB) 和细胞因子IL-18/IL-10是关键的炎症调解剂,但它们在良性前列腺增生 (BPH) 和职业相关前列腺癌风险中的作用尚未得到研究.
研究的目的:
- 在前列腺癌,BPH和健康个体中研究NF-κB亚单元 (p65,p50) 和细胞因子 (IL-18,IL-10) 的表达.
- 检查这些标记物与前列腺癌阶段,转移状态和职业暴露的关联.
主要方法:
- 定量实时PCR (qRT-PCR) 和ELISA用于分析664名参与者 (285名前列腺癌,94名BPH,285名对照) 的NF-κB和细胞因子的mRNA和蛋白质水平.
- 进行了统计分析,包括双向ANOVA和相关性分析,以评估群体差异和标记物和临床因素之间的关系.
主要成果:
- 与BPH和对照组相比,NF-κB p65/p50和IL-18/IL-10在前列腺癌中显著上调 (p < 0.0001).
- 生物标志物表达与晚期癌症阶段和转移状态正相关.
- 皮革工人表达最高;在NF-κB子单元和细胞因子之间观察到显著的正相关性.
结论:
- NF-κB及其下游细胞因子 (IL-18,IL-10) 显示出作为前列腺癌的非侵入性,炎症驱动生物标志物的潜力.
- 这些标记可能有助于诊断,分期和风险分层,特别是对于环境或职业暴露的人来说.
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