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相关概念视频

What is Gene Expression?01:42

What is Gene Expression?

195.1K
Overview
Gene expression is the process in which DNA directs the synthesis of functional products, that is, proteins. Cells can regulate gene expression at various stages. It allows organisms to generate different cell types and enables cells to adapt to internal and external factors.
Genetic Information Flows from DNA to RNA to Protein
A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is made up of nucleotides and proteins consist of amino...
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What is Gene Expression?01:36

What is Gene Expression?

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A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is comprised  of nucleotides and proteins are comprised of amino acids, a mediator is required to convert the information encoded in DNA into proteins. This mediator is the messenger RNA (mRNA). mRNA copies the blueprint from DNA by a process called transcription. In eukaryotes, transcription occurs in the nucleus by complementary base-pairing with the DNA template. The mRNA is then...
11.1K
Chromatin Position Affects Gene Expression02:35

Chromatin Position Affects Gene Expression

24.7K
Chromatin is the massive complex of DNA and proteins packaged inside the nucleus. The complexity of chromatin folding and how it is packaged inside the nucleus greatly influences  access to genetic information. Generally, the nucleus' periphery is considered transcriptionally repressive, while the cell's interior is considered a transcriptionally active area. 
Topologically Associated Domains (TADs)
The 3-dimensional positioning of chromatin in the nucleus influences the...
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Cell Specific Gene Expression01:58

Cell Specific Gene Expression

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Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
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Cell Specific Gene Expression01:58

Cell Specific Gene Expression

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mRNA Stability and Gene Expression02:51

mRNA Stability and Gene Expression

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The structure and stability of mRNA molecules regulates gene expression, as mRNAs are a key step in the pathway from gene to protein. In eukaryotes, the half-life of mRNA varies from a few minutes up to several days. mRNA stability is essential in growth and development. The absence of the proteins regulating its stability, such as tristetraprolin in mice, can cause systemic issues, including bone marrow overgrowth, inflammation, and autoimmunity.
Cis-acting Elements involved in mRNA stability
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CRISPR Gene Editing Tool for MicroRNA Cluster Network Analysis
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集群GVis:用于基因表达分析的高级可视化和集群工具.

Jun Zhang1,2, Hongyuan Li1,2, Wenjun Tao1,2

  • 1State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 211198, China.

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概括

ClusterGVis是一个新的生物信息学工具,简化了基因表达分析和可视化. 它有助于研究人员识别生物标志物,并利用聚类和热图特征了解基因功能.

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大量的RNA测序.功能注释功能注释模糊的c-意味着集群.基因聚类可视化可视化一个单细胞RNA测序.

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科学领域:

  • 生物信息学是一种生物信息学.
  • 计算生物学 计算生物学
  • 基因组学就是基因组学.

背景情况:

  • 从单细胞RNA测序 (scRNA-seq) 和散装RNA测序 (bulk RNA-seq) 来解释大规模的基因表达数据对于理解生物系统至关重要.
  • 有效的分析和可视化工具对于从复杂的转录数据集中提取有意义的见解至关重要.

研究的目的:

  • 介绍ClusterGVis,这是一个先进的生物信息软件,旨在简化基因表达数据的分析和可视化.
  • 为研究人员提供一个用户友好的平台,以揭示转录组数据集中的模式和关系.

主要方法:

  • 使用模糊的c-means和k-means集群算法进行转录基因数据分析.
  • 具有集成的热图可视化功能,用于探索共同表达网络和识别差异表达的基因.
  • 提供了一个用户友好的界面,用于简化数据解释.

主要成果:

  • 能够有效地识别复杂基因表达特征中的模式和关系.
  • 便于直观地探索共同表达网络,并识别差异表达的基因.
  • 支持识别潜在的生物标志物,并增强对基因功能的理解.

结论:

  • 集群GVis简化了复杂的基因表达数据分析和可视化.
  • 该软件有助于发现生物标志物和阐明基因调节机制.
  • 公开可用的资源,包括教程和Shiny App,提高了可访问性和可用性.