介电离子导电性作为一种生物标志物用于化使用纳米-ZnO/CMC在白色老鼠
Faith Geoffrey1, Victor M Ahur2, Solomon T Agu2
1Department of Physics, Joseph Sarwuan Tarka University Makurdi, Nigeria.
概括
这项研究表明,测量血液介电离子导电性可以帮助诊断大鼠的 (Pb) 暴露. 纳米氧化/碳素甲基纤维素 (nZnO/CMC) 有效降低了毒性,并恢复了血液参数.
科学领域:
- 环境毒理学环境毒理学
- 生物材料科学是生物材料的科学.
- 纳米技术 纳米技术
背景情况:
- (Pb) 暴露对健康构成重大风险,需要可靠的诊断工具.
- 目前用于毒性的诊断方法可能是侵入性的或耗时的.
- 纳米材料为重金属中毒提供了潜在的治疗策略.
研究的目的:
- 为了评估介电导电性作为生物标志物 (Pb) 水平在白色大鼠.
- 调查纳米-ZnO-caped碳素甲基纤维素 (nZnO/CMC) 对诱导毒性的改善作用.
- 评估nZnO/CMC作为潜在治疗剂的安全性和有效性.
主要方法:
- 白色大鼠被暴露在 (Pb) 中61天,随后使用合成的nZnO/CMC.进行治疗.
- 血液学参数和红细胞表面酸被分析.
- 血液样本的电介导率在一个频率范围 (200 Hz4 MHz) 中被测量.
- 使用X射线衍射来描述合成的nZnO/CMC纳米粒子.
主要成果:
- 暴露于引发了贫血,通过减少细胞密集量,红细胞计数,白细胞计数和血红蛋白度证明了这一点.
- nZnO/CMC的使用恢复了血液学参数和红细胞表面酸,表明了Pb化特性.
- 电介导率在Pb暴露样本中最高,在对照样本中最低,在nZnO/CMC治疗时呈现剂量依赖的下降.
- 毒性研究证实nZnO/CMC在剂量高达2000mg/kg体重时是无毒的.
结论:
- 血液的电介离子导电性是检测 (Pb) 暴露在动物模型中的敏感且有前途的生物标志物.
- 由于其Pb化能力和安全性,nZnO/CMC显示出作为减轻毒性的治疗剂的巨大潜力.
- 这项研究强调了介电离子导电性变化与暴露度之间的相关性,提供了一种新的诊断方法.
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