在非线性混合效应模型中用于共变选择的稳定性增强的拉索方法
Auriane Gabaut1,2,3, Rodolphe Thiébaut1,2,3,4, Cécile Proust-Lima1
1University of Bordeaux, INSERM, BPH, Bordeaux, France.
Statistics in medicine
|January 22, 2026
概括
本研究介绍了Lasso-SAMBA,这是一种用于选择复杂生物模型中重要变量的新方法. 它提高了准确性,并减少了高维数据中的错误,增强了系统疫苗学研究.
科学领域:
- 系统生物学 系统生物学
- 计算生物学 计算生物学
- 制药指标 (Pharmacometrics) 是一个指标.
背景情况:
- 使用普通微分方程 (ODEs) 的非线性混合效应模型 (NLMEM) 对于分析动态生物系统至关重要.
- 对于这些模型来说,在高维数据中确定相关的共变量是一个重大挑战.
研究的目的:
- 在基于ODE的NLMEM中开发一种可靠的共变量选择方法.
- 改进复杂生物系统中的模型构建,特别是在高维环境中.
主要方法:
- 介绍了拉索-SAMBA (模型构建算法的随机近似),将拉索回归与稳定性选择集成在一起.
- 代模型构建合惩罚回归与机械模型估计通过SAEM算法.
- 扩展以前的SAMBA战略,采用惩罚性,以稳定性为导向的方法来提高稳定性和减少虚假发现.
主要成果:
- 拉索-SAMBA在模拟中展示了卓越的变量选择忠实性,错误发现比例 (FDR) 控制和计算效率.
- 该方法的性能优于传统的步骤和贝叶斯变量选择技术.
- 应用到疹病毒疫苗接种研究揭示了免疫反应模型参数和早期转录体表达之间的强有力的关联.
结论:
- 拉索-SAMBA为基于ODE的NLMEM中的高维共变量选择提供了一种强大而稳健的方法.
- 该方法在系统疫苗学和其他涉及复杂生物建模的领域具有实用用途.
- 在R包的实施促进了Lasso-SAMBA在研究中的应用.
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