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Quality Assurance01:19

Quality Assurance

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Quality assurance is the overarching term used to describe the activities employed to ensure the proper performance of a system. These activities can be classified into three categories: quality control, quality assessment, and internal corrective measures. Typically, these activities work cyclically: quality control is performed before and during the analysis, while quality assessment occurs during and after the investigation. Internal corrective measures are implemented based on the findings...
1.1K
Exceptions to the Octet Rule02:55

Exceptions to the Octet Rule

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Many covalent molecules have central atoms that do not have eight electrons in their Lewis structures. These molecules fall into three categories:
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Lewis Symbols and the Octet Rule02:36

Lewis Symbols and the Octet Rule

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Chemical bonds are complex interactions between two or more atoms or ions, which reduce the potential energy of the molecule. Gilbert N. Lewis developed a model called the Lewis model that simplified the depiction of chemical bond formation and provided straightforward explanations for the chemical bonds seen in most common compounds.
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The Aufbau Principle and Hund's Rule03:02

The Aufbau Principle and Hund's Rule

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To determine the electron configuration for any particular atom, we can build the structures in the order of atomic numbers. Beginning with hydrogen, and continuing across the periods of the periodic table, we add one proton at a time to the nucleus and one electron to the proper subshell until we have described the electron configurations of all the elements. This procedure is called the aufbau principle, from the German word aufbau (“to build up”). Each added electron occupies the...
72.4K
The Quotient Rule01:30

The Quotient Rule

49
The quotient rule is a fundamental differentiation technique in calculus used to differentiate functions expressed as a ratio of two differentiable functions. Given a function of the form:Where g(x) and h(x) are both differentiable and h(x) ≠ 0, the derivative of f(x) is given by:Example:The quotient rule is beneficial when differentiating rational functions, trigonometric ratios, and exponential functions. For example, given:applying the quotient rule,This rule is essential in solving...
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Midpoint Rule01:20

Midpoint Rule

55
Approximating areas under curved boundaries is a common problem in applied mathematics, particularly when an exact calculation is difficult or impractical. One effective numerical method for this purpose is the Midpoint Rule, which provides an estimate of the area under a curve by using rectangular approximations over a specified interval.Description of the Midpoint RuleThe Midpoint Rule begins by dividing the given interval into a number of equal subintervals. For each subinterval, the...
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Using Informational Connectivity to Measure the Synchronous Emergence of fMRI Multi-voxel Information Across Time
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基于有条件保证的信息徒劳性规则

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  • 1Quantitative Sciences and Clinical Pharmacology, Johnson & Johnson, Spring House, Pennsylvania, USA.

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概括
此摘要是机器生成的。

徒劳性规则有助于制药试验在不太可能成功的情况下提前停止,从而节省资源. 条件保证为这些规则提供了一个新的,信息化的方法,平衡风险并改善决策.

关键词:
确保保证的保证.有条件的保证保证.有条件功率的条件功率.徒劳的规则统治徒劳的规则.预测能力的预测能力.预测成功概率的成功概率.对样本大小进行重新估计.

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科学领域:

  • 临床试验设计 临床试验设计
  • 制药统计 制药统计

背景情况:

  • 徒劳性规则使得临床试验的早期终止不太可能达到疗效终点.
  • 由于经济和道德考虑,这些规则对于药物开发中的资源优化至关重要.

研究的目的:

  • 审查现有的徒劳规则方法,并引入一种名为条件保证的新方法.
  • 解决当前措施的缺陷,如条件功率和成功的预测概率,特别是在样本大小重新估计设计.

主要方法:

  • 概述条件力,成功的预测概率和贝叶斯式成功的预测概率.
  • 介绍和解释条件保证作为替代无用规则指标.
  • 使用案例研究来比较不同的徒劳规则方法的演示.

主要成果:

  • 现有的无用性测量有缺点,特别是对样本大小的重新估计.
  • 条件保证不需要预期治疗效果的估计,使其适合于有信息的无用性规则.
  • 条件保证平衡了停止徒劳的概率,其自身价值和整体试验功率.

结论:

  • 条件保证为制药试验中制定信息无用性规则提供了一个强大的替代方案.
  • 这一指标有助于决策者了解和管理与早期试验终止相关的风险.
  • 有关风险分配的明智决策可以基于组织的容忍度.