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解锁时钟:心血管疾病预防的最佳体力活动时间
Yujia Liu1, Sheng Zhong2, Guowei Liu3
1Institute of Physical Education, Jiangsu Normal University, Xuzhou, JS, China.
Journal of physical activity & health
|January 22, 2026
概括
定时进行体力活动 (PA) 可以降低心血管疾病的风险. 早晨和下午的运动显示出对中风和动脉样硬化的保护作用,而晚上的活动也可能有利于预防中风.
科学领域:
- 心血管流行病学心血管流行病学
- 遗传学和个性化医学
- 时间生物学和运动生理学.
背景情况:
- 心血管疾病 (CVD) 仍然是全球主要的死亡原因.
- 了解可修改的风险因素,如身体活动 (PA) 时间,对于预防至关重要.
- 以前的研究还没有完全阐明PA对各种心血管疾病亚型的特定时间影响.
研究的目的:
- 调查一天中不同时间体育活动 (PA) 对主要心血管疾病风险的因果关系.
- 为了区分PA时间对中风亚型,心力衰竭,动脉样硬化,心肌梗塞,高血压和外周动脉疾病的影响.
主要方法:
- 采用两个样本的门德尔随机化 (MR) 分析,包括单变量和多变量.
- 使用了来自英国生物银行的总PA和12个特定的2小时间隔的遗传仪器.
- 从大规模的联盟中获得了关于心血管疾病结果的总结级数据,并应用了多种MR估计方法.
主要成果:
- 晨间 (6-8 AM) 和中午 (10 AM-12 PM) PA 证明了独立的保护作用,防止总和缺血性中风.
- 特定的晚上PA (6-8PM) 也显示了与中风亚型的保护性关联.
- 某些白天的PA间隔与降低动脉样硬化和高血压风险有关,尽管影响因亚型和MR方法而异.
结论:
- 身体活动的时间因果关系与特定心血管疾病的风险有关,特别是中风,动脉样硬化和高血压.
- 这些发现强调了考虑运动时间的重要性,以优化心血管疾病预防策略.
- 进一步的研究可能会为不同人群和心血管疾病风险改进最佳的PA时间表.
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